Mannich aminomethylation of flavonoids and anti-proliferative activity against breast cancer cell
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Papers"
DOI: 10.1007/s11696-018-0402-1
Abstract: We herein report Mannich aminomethylation of variously structural flavonoids and their biological evaluation against human breast cancer cell. Mannich reaction showed that substitution at C-6 position depends on amine basicity and C-ring feature of flavonoids.… read more here.
Keywords: anti proliferative; aminomethylation; breast cancer; cancer cell ... See more keywords
Effect of lithium carbonate on autophagy and proliferative activity of isolated hepatocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.057
Abstract: The hepatocytes were cultivated in the presence of lithium carbonate (LC) for drugs testing or possible source for transplantation in the treatment of hereditary or terminal liver diseases. The LC, as an inducer of autophagy,… read more here.
Keywords: effect; proliferative activity; lithium carbonate;
Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.038
Abstract: Quinoline derivatives 2, 3, quinolinyl based pyrazolines 4a,b, 5 and quinolinyl pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their anti-proliferative activity against MCF-7, HeLa and DLD1 cancer cell lines as… read more here.
Keywords: anti proliferative; egfr inhibitors; quinoline; thiazole hybrids ... See more keywords
Phenolic content and in vitro antioxidant activity in common beans (Phaseolus vulgaris L.) are not directly related to anti-proliferative activity
Sign Up to like & getrecommendations! Published in 2020 at "Food bioscience"
DOI: 10.1016/j.fbio.2020.100662
Abstract: Abstract Antioxidant, anti-proliferative activities, and phytochemical profiles of common bean extracts were measured and compared in 10 common bean cultivars. Among the cultivars, a Yunnan cultivar (YN-1) contained the highest total phenolic content (423 mg GAE/100 g… read more here.
Keywords: antioxidant activity; anti proliferative; content; proliferative activity ... See more keywords
Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Steroids"
DOI: 10.1016/j.steroids.2020.108638
Abstract: Cholest-4-ene-3,6-dione (KS) is a cholesterol oxidation product which exhibits anti-proliferative activity. However, its precise mechanism of action remains unknown. In this study, the effects of KS on AKR1C3 inhibition and anti-proliferative activities were investigated in… read more here.
Keywords: anti proliferative; cholest ene; mcf; inhibition ... See more keywords
Facile and expedient synthesis and anti-proliferative activity of diversely pyrrolones bearing 1,3-diphenylpyrazole moiety
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1691737
Abstract: Abstract A series of some pyrrolone derivatives were synthesized from the acid hydrazide, derived from a pyrazolyl-2(3H)-furanone, through treating with some carbonyl reagents such as 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde, formic acid, lauroyl chloride, succinoyl chloride, propionic anhydride, as… read more here.
Keywords: facile expedient; anti proliferative; expedient synthesis; synthesis anti ... See more keywords
Design, synthesis, anti-proliferative activity, and molecular docking studies of novel benzo[f]chromene, chromeno [2,3-d]pyrimidines and chromenotriazolo[1,5-c]pyrimidines
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1710850
Abstract: Abstract In seeking to establish new anticancer agents, a group of novel substituted chromeno[2,3-d]pyrimidine and chromenotriazolo[1,5-c]pyrimidine derivatives were designed and synthesized as potential anti-proliferative agents. Chromeno[2,3-d]pyrimidine derivatives were prepared via reaction of ethyl formimidate derivative… read more here.
Keywords: anti proliferative; docking studies; pyrimidine derivatives; proliferative activity ... See more keywords
The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "International Immunology"
DOI: 10.1093/intimm/dxac042
Abstract: Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, and many peripheral immune cell populations (ICPs) are thought to be altered according to the course of the disease. However, it is unclear which ICPs… read more here.
Keywords: cell; clinical phenotypes; proliferative activity; systemic lupus ... See more keywords
Time-lapse imaging of HeLa spheroids in soft agar culture provides virtual inner proliferative activity
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231774
Abstract: Cancer is a complex disease caused by multiple types of interactions. To simplify and normalize the assessment of drug effects, spheroid microenvironments have been utilized. Research models that involve agent measurement with the examination of… read more here.
Keywords: proliferative activity; virtual inner; inner proliferative; time lapse ... See more keywords
Sterols from Centaurea pumilio L. with cell proliferative activity: In vitro and in silico studies
Sign Up to like & getrecommendations! Published in 2023 at "Open Chemistry"
DOI: 10.1515/chem-2022-0316
Abstract: Abstract Numerous studies highlighted the impact of natural products, particularly phytosterols, in wound healing while providing less expensive alternatives to chemically synthesized drugs, with less side effects. Centaurea pumilio L. (family Asteraceae) is a rare… read more here.
Keywords: sterols centaurea; cell; chemistry; proliferative activity ... See more keywords
Pulsed Electromagnetic Field Stimulation Promotes Anti-cell Proliferative Activity in Doxorubicin-treated Mouse Osteosarcoma Cells.
Sign Up to like & getrecommendations! Published in 2017 at "In vivo"
DOI: 10.21873/invivo.11026
Abstract: AIM We aimed to investigate the synergistic effects of pulsed electromagnetic field (PEMF) and doxorubicin therapy in a mouse osteosarcoma cell line (LM8 cells) in vitro. MATERIALS AND METHODS The effects of PEMF (5 mT,… read more here.
Keywords: mouse osteosarcoma; electromagnetic field; doxorubicin; proliferative activity ... See more keywords