RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
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DOI: 10.1038/s41467-021-23186-w
Abstract: Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is associated with dismal outcomes. RAS pathway mutations, mainly NRASG12D, define the pCMML phenotype as demonstrated by our exome sequencing, progenitor colony assays and a Vav-Cre-NrasG12D… read more here.
Keywords: plk1; ras mutations; chronic myelomonocytic; proliferative chronic ... See more keywords