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Published in 2021 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2021.101219
Abstract: Purpose The pathogenesis of proliferative vitreoretinopathy (PVR), the most important cause of retinal detachment surgery failure, is still not fully understood. We previously hypothesized a causal link between vitreoschisis-induced vitreous cortex remnants (VCR) and PVR… read more here.
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Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.02.006
Abstract: ABSTRACT Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment failure. The mechanism of PVR development is complex and still not completely elucidated. There are no proven methods for early prevention or clinical treatment.… read more here.
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Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1833382
Abstract: Abstract Proliferative vitreoretinopathy (PVR) is a significant threat for vision recovery from retinal detachment or ocular trauma. Currently, no approved pharmacological intervention to prevent PVR. Daunorubicin (DNR) and dexamethasone (DEX) were sequentially loaded into oxidized… read more here.
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Published in 2021 at "Retina"
DOI: 10.1097/iae.0000000000003250
Abstract: Satisfactory anatomical and functional outcome is possible after nonprimary retinectomy for retinal redetachment with proliferative vitreoretinopathy. The normal macular profile was rarely found (3% of cases), whereas majority demonstrated exudative maculopathy, macular atrophy, and tractional… read more here.
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Published in 2022 at "Retina"
DOI: 10.1097/iae.0000000000003391
Abstract: PURPOSE The purpose of this study was to investigate the clinical outcomes of optimized method in order to clearly remove the subretinal proliferative tissue by trans-scleral puncture into the subretinal space in Grade C proliferative… read more here.
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Published in 2022 at "Current Opinion in Ophthalmology"
DOI: 10.1097/icu.0000000000000840
Abstract: Purpose of review Despite advancement in the surgical instrumentation and techniques, proliferative vitreoretinopathy (PVR) remains the most common cause for failure of rhegmatogenous retinal detachment (RRD) repair. This review discusses ongoing translational and clinical advancements… read more here.
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Published in 2020 at "Journal of Ophthalmology"
DOI: 10.1155/2020/6938627
Abstract: Purpose To evaluate the efficacy and safety of the simultaneous use of short-term perfluoro-n-octane (PFO) with perfluoropropane (C3F8) gas to achieve retinal reattachment in eyes with rhegmatogenous retinal detachment (RRD) with proliferative vitreoretinopathy (PVR) grade… read more here.
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Published in 2019 at "Ophthalmologica"
DOI: 10.1159/000500271
Abstract: Purpose: To evaluate the effects of repeated intra-silicone oil (SO) injections of methotrexate (MTX) on the outcomes of surgery for rhegmatogenous retinal detachment (RRD) with grade C proliferative vitreoretinopathy (PVR-C). Methods: In this prospective pilot… read more here.
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Published in 2021 at "Case Reports in Ophthalmology"
DOI: 10.1159/000512285
Abstract: Premacular membranes developing following pars plana vitrectomy (PPV) can cause significant anatomical and functional deficits to the macula. Recent reports showed that postoperative premacular membranes are a localized presentation of macular proliferative vitreoretinopathy (mPVR). Here,… read more here.
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Published in 2022 at "Ophthalmic Research"
DOI: 10.1159/000525530
Abstract: Multiple lines of evidence support an immunologic response along with inflammation to be implicated in the pathophysiology of primary rhegmatogenous retinal detachment (RRD) and the development of proliferative vitreoretinopathy (PVR). The purpose of this review… read more here.
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Published in 2021 at "BMC Medical Genomics"
DOI: 10.1186/s12920-021-00875-5
Abstract: Background Peripheral immune response has been revealed to play a critical role in proliferative vitreoretinopathy (PVR). However, the reliable immune-related factors that are acting as prognostic indicators or therapeutic targets for PVR remain to explore… read more here.