Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00670
Abstract: E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved in many cellular processes by acting as coactivators of a large number of… read more here.
Keywords: p300; proline based; p300 cbp; inhibitors using ... See more keywords
Spectroscopic characterization and reactivity of a high valent (L)Cu(III) species supported by proline-based pseudo peptide
Sign Up to like & getrecommendations! Published in 2023 at "Dalton Transactions"
DOI: 10.1039/d3dt00697b
Abstract: Inspired by copper-based metalloenzymes, we aim to incorporate amino acids into our ligands to facilitate active copper intermediates that serve as functional and structural models for these enzymes. Herein, we report the synthesis of a… read more here.
Keywords: reactivity high; proline based; characterization reactivity; high valent ... See more keywords