Dimerization of Proline Dehydrogenase from Thermus thermophilus Is Crucial for Its Thermostability.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201800540
Abstract: Thermus thermophilus proline dehydrogenase ( TtProDH) catalyzes the first step in proline catabolism. The thermostable flavoenzyme consists of a distorted triosephosphate isomerase (TIM) barrel and three N-terminal helices: αA, αB, and αC. Using maltose-binding protein… read more here.
Keywords: proline dehydrogenase; dimerization; thermostability; thermus ... See more keywords
Proline dehydrogenase-entrapped mesoporous magnetic silica nanomaterial for electrochemical biosensing of L-proline in biological fluids.
Sign Up to like & getrecommendations! Published in 2017 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.05.007
Abstract: In this work, physical adsorption was used for immobilization of proline dehydrogenase onto a magnetic mesoporous silica nanomaterial. The immobilization and electrocatalytical activity of proline dehydrogenase entrapped in a magnetic mesoporous silica nanomaterial was studied… read more here.
Keywords: proline dehydrogenase; silica nanomaterial; proline; cell ... See more keywords
Proline dehydrogenase promotes senescence through the generation of reactive oxygen species
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.196469
Abstract: ABSTRACT Cellular senescence is a complex stress response characterized by permanent loss of proliferative capacity and is implicated in age-related disorders. Although the transcriptional activity of p53 (encoded by TP53) is known to be vital… read more here.
Keywords: proline dehydrogenase; senescence; reactive oxygen; oxygen species ... See more keywords
Tea Polyphenol Epigallocatechin-3-Gallate Inhibits Cell Proliferation In a Patient-Derived Triple-Negative Breast Cancer Xenograft Mouse Model Via Inhibition of Proline-Dehydrogenase-Induced Effects
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Food and Drug Analysis"
DOI: 10.38212/2224-6614.3230
Abstract: Triple-negative breast cancers (TNBCs) lack specific targeted therapy options and have evolved into highly chemoresistant tumors that metastasize to multiple organs. The present study demonstrated that the proline dehydrogenase (PRODH)mRNA level in paired (tumor vs.… read more here.
Keywords: prodh; proline dehydrogenase; negative breast; breast ... See more keywords