Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219419120
Abstract: Prolyl hydroxylase domain (PHD) enzymes change HIF activity according to oxygen signal; whether it is regulated by other physiological conditions remains largely unknown. Here, we report that PHD3 is induced by fasting and regulates hepatic… read more here.
Keywords: hydroxylation crtc2; phd3; hydroxylation; proline hydroxylation ... See more keywords
Glutaminolysis Promotes Collagen Translation and Stability via &agr;‐Ketoglutarate‐mediated mTOR Activation and Proline Hydroxylation
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DOI: 10.1165/rcmb.2017-0238oc
Abstract: Abstract Glutaminolysis is the metabolic process of glutamine, aberration of which has been implicated in several pathogeneses. Although we and others recently found a diversity of metabolic dysregulation in organ fibrosis, it is unknown if… read more here.
Keywords: agr; collagen translation; proline hydroxylation; translation stability ... See more keywords
HypDB: A functionally annotated web-based database of the proline hydroxylation proteome
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DOI: 10.1371/journal.pbio.3001757
Abstract: Proline hydroxylation (Hyp) regulates protein structure, stability, and protein–protein interaction. It is widely involved in diverse metabolic and physiological pathways in cells and diseases. To reveal functional features of the Hyp proteome, we integrated various… read more here.
Keywords: hyp; hypdb; analysis; proteome ... See more keywords