Single-Molecule SERS Discrimination of Proline from Hydroxyproline Assisted by a Deep Learning Model
Sign Up to like & getrecommendations! Published in 2025 at "Nano Letters"
DOI: 10.1021/acs.nanolett.5c01177
Abstract: Discriminating low-abundance hydroxylation is a crucial and unmet need for early disease diagnostics and therapeutic development due to the small hydroxyl group with 17.01 Da. While single-molecule surface-enhanced Raman spectroscopy (SERS) sensors can detect hydroxylation,… read more here.
Keywords: molecule; proline hydroxyproline; model; molecule sers ... See more keywords
The regulatory mechanisms of proline and hydroxyproline metabolism: Recent advances in perspective
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1118675
Abstract: For diverse human tumors, growth and metastasis are dependent on proline synthesis, but the mechanisms underlying this association are not clear. Proline incorporated into collagen is primarily synthesized from glutamine. Thus, rates of collagen synthesis… read more here.
Keywords: metabolism; proline hydroxyproline; collagen; hydroxyproline ... See more keywords