PYCR, a key enzyme in proline metabolism, functions in tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03047-y
Abstract: Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth… read more here.
Keywords: key enzyme; enzyme proline; pycr key; proline metabolism ... See more keywords
Epibrassinolide reverses the stress generated by combination of excess aluminum and salt in two wheat cultivars through altered proline metabolism and antioxidants
Sign Up to like & getrecommendations! Published in 2017 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2017.06.034
Abstract: Abstract This study was conducted to unravel the EBL mediated changes on the enzymes of proline metabolism under combined stress of aluminum and salt through varied mode of application. The results of the study revealed… read more here.
Keywords: aluminum salt; aluminum; proline metabolism; stress ... See more keywords
The Janus-like role of proline metabolism in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-00341-8
Abstract: The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes,… read more here.
Keywords: role proline; metabolism; metabolism cancer; proline metabolism ... See more keywords
Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18704-1
Abstract: Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondrial calcium uniporter (MCU), a multi-protein complex whose assembly in the… read more here.
Keywords: metabolism; proline metabolism; mitochondrial proline; human mcur1 ... See more keywords
Modified Proline Metabolism and Prolidase Enzyme in COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory Medicine"
DOI: 10.1093/labmed/lmac017
Abstract: Abstract Objective The aim of the study was to evaluate proline metabolism in patients affected by COVID-19. Materials and Methods This case-control study consisted of 116 patients with COVID-19 and 46 healthy individuals. Tests related… read more here.
Keywords: proline metabolism; metabolism; metabolism prolidase; prolidase enzyme ... See more keywords
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262364
Abstract: Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There… read more here.
Keywords: cancer; biosynthesis; cancer cells; proline metabolism ... See more keywords
Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006158
Abstract: Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the… read more here.
Keywords: brucei; trypanosoma brucei; proline metabolism; proline ... See more keywords
Proline Metabolism in Neurological and Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.0115
Abstract: Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of… read more here.
Keywords: metabolism neurological; metabolism; psychiatric disorders; proline metabolism ... See more keywords
Interactive Regulation of Hormone and Resistance Gene in Proline Metabolism Is Involved in Effector-Triggered Immunity or Disease Susceptibility in the Xanthomonas campestris pv. campestris–Brassica napus Pathosystem
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.738608
Abstract: To characterize cultivar variations in hormonal regulation of the transition between pattern-triggered immunity (PTI) and effector-triggered immunity or susceptibility (ETI or ETS), the responses of resistance (R-) genes, hydrogen peroxide, and proline metabolism in two… read more here.
Keywords: triggered immunity; disease; disease susceptibility; proline metabolism ... See more keywords
Arbuscular mycorrhizal fungi enhanced rice proline metabolism under low temperature with nitric oxide involvement
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.962460
Abstract: Arbuscular mycorrhizal fungi (AMF) are known to improve plant stress tolerance by regulating proline accumulation, and nitric oxide (NO) plays an important signaling role in proline metabolism. Environmental nitrogen (N) affects AMF colonization and its… read more here.
Keywords: proline metabolism; low temperature; temperature; rice ... See more keywords
H2O2-Responsive Hormonal Status Involves Oxidative Burst Signaling and Proline Metabolism in Rapeseed Leaves
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11030566
Abstract: Drought alters the level of endogenous reactive oxygen species (ROS) and hormonal status, which are both involved in the regulation of stress responses. To investigate the interplay between ROS and hormones in proline metabolism, rapeseed… read more here.
Keywords: metabolism rapeseed; hormonal status; exo h2o2; h2o2 ... See more keywords