Kinetic and Thermodynamic Characterization of Human 4-Oxo-l-proline Reductase Catalysis
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.4c00721
Abstract: The enzyme 4-oxo-l-proline reductase (BDH2) has recently been identified in humans. BDH2, previously thought to be a cytosolic (R)-3-hydroxybutyrate dehydrogenase, actually catalyzes the NADH-dependent reduction of 4-oxo-l-proline to cis-4-hydroxy-l-proline, a compound with known anticancer activity.… read more here.
Keywords: chemistry; proline; oxo proline; proline reductase ... See more keywords
d-Proline Reductase Underlies Proline-Dependent Growth of Clostridioides difficile
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00229-22
Abstract: Stickland metabolism is a core facet of C. difficile physiology that likely plays a major role in host colonization. Here, we carefully delineate the effects of each amino acid on the growth of C. difficile… read more here.
Keywords: growth; difficile; physiology; proline reductase ... See more keywords