Proline C−H Bonds as Loci for Proline Assembly via C−H/O Interactions
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DOI: 10.1002/cbic.202200409
Abstract: Proline residues within proteins lack a traditional hydrogen bond donor. However, the hydrogens of the proline ring are all sterically accessible, with polarized C−H bonds at Hα and Hδ that exhibit greater partial positive character… read more here.
Keywords: recognition; proline bonds; via interactions; proline residues ... See more keywords
Structural Variants of a Liver Fluke Derived Granulin Peptide Potently Stimulate Wound Healing.
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DOI: 10.1021/acs.jmedchem.8b00898
Abstract: Granulins are a family of growth factors involved in cell proliferation. The liver-fluke granulin, Ov-GRN-1, isolated from a carcinogenic liver fluke Opisthorchis viverrini, can significantly accelerate wound repair in vivo and in vitro. However, it… read more here.
Keywords: variants liver; wound healing; liver fluke; fluke derived ... See more keywords
Enzymatic Modification of N-Terminal Proline Residues Using Phenol Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10845
Abstract: A convenient enzymatic strategy is reported for the modification of proline residues in the N-terminal positions of proteins. Using a tyrosinase enzyme isolated from Agaricus bisporus (abTYR), phenols and catechols are oxidized to highly reactive… read more here.
Keywords: proline residues; terminal proline; enzymatic modification; modification ... See more keywords
Conserved Proline Residues of Bacillus subtilis Intramembrane Metalloprotease SpoIVFB Are Important for Substrate Interaction and Cleavage
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00386-21
Abstract: Intramembrane metalloproteases (IMMPs) function in numerous signaling pathways. Bacterial IMMPs govern stress responses, including the sporulation of some species, thus enhancing the virulence and persistence of pathogens. ABSTRACT Intramembrane metalloproteases (IMMPs) regulate diverse biological processes… read more here.
Keywords: cleavage; proline residues; short loop; substrate ... See more keywords