The proline‐rich domain of fission yeast WASp (Wsp1p) interacts with actin filaments and inhibits actin polymerization
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14571
Abstract: Members of the Wiskott–Aldrich Syndrome protein (WASp) family activate Arp2/3 complex (actin‐related proteins 2 and 3 complex) to form actin filament branches. The proline‐rich domain (PRD) of WASp contributes to branching nucleation, and the PRD… read more here.
Keywords: actin filaments; rich domain; proline rich; actin ... See more keywords
Proline-Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology journal"
DOI: 10.1002/biot.201700479
Abstract: Human butyrylcholinesterase (BChE), predominantly tetramers with a residence time of days, offers the potential to scavenge organophosphorus pesticides and chemical warfare agents. Efficient assembly of human BChE into tetramers requires an association with proline-rich peptide… read more here.
Keywords: rich chaperones; cho cells; rbche; proline rich ... See more keywords
Enzymatic Synthesis Assisted Discovery of Proline‐Rich Macrocyclic Peptides in Marine Sponges
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100275
Abstract: Proline‐rich macrocyclic peptides (PRMPs) are natural products present in geographically and phylogenetically dispersed marine sponges. The large diversity and low abundance of PRMPs in sponge metabolomes precludes isolation and structure elucidation of each individual PRMP… read more here.
Keywords: enzymatic synthesis; macrocyclic peptides; marine sponges; rich macrocyclic ... See more keywords
Proline‐rich transmembrane protein 2 specifically binds to GluA1 but has no effect on AMPA receptor‐mediated synaptic transmission
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24196
Abstract: Proline‐rich transmembrane protein 2 (PRRT2) is a neuron‐specific protein associated with seizures, dyskinesia, and intelligence deficit. Previous studies indicate that PRRT2 regulates neurotransmitter release from presynaptic membranes. However, PRRT2 can also bind AMPA‐type glutamate receptors… read more here.
Keywords: transmembrane protein; proline rich; rich transmembrane; protein ... See more keywords
ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03610-y
Abstract: SAM68 is an mRNA-binding protein involved in mRNA processing in the nucleus that forms membraneless compartments called SAM68 Nuclear Bodies (SNBs). We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3… read more here.
Keywords: sam68 proline; proline rich; sh3; sh3 domain ... See more keywords
Correlating uptake and activity of proline-rich antimicrobial peptides in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0496-2
Abstract: AbstractIncreasing death tolls accounted for by antimicrobial drug resistance demand novel antibiotic lead compounds. Among different promising candidate classes, proline-rich antimicrobial peptides (PrAMPs) are very favorable due to their intracellular mechanism, i.e., binding to the 70S… read more here.
Keywords: escherichia coli; correlating uptake; antimicrobial peptides; rich antimicrobial ... See more keywords
Megaherbivore browsers vs. tannins: is being big enough?
Sign Up to like & getrecommendations! Published in 2020 at "Oecologia"
DOI: 10.1007/s00442-020-04784-9
Abstract: Megaherbivores have been of particular interest to scientists because of the physiological and ecological challenges associated with their extreme body size. Yet, one question that has seldom been explored is how browsing megaherbivores cope with… read more here.
Keywords: binding proteins; tannin; tannin binding; proline rich ... See more keywords
The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.01.019
Abstract: Src homology 3 or SH3 domains constitute one of the most common protein domains in signal transduction, generally characterized by their binding to proline-rich sequences on interacting signaling proteins. Caskin1, a scaffold protein regulating cortical… read more here.
Keywords: caskin1; sh3 domain; lysophosphatidic acid; proline rich ... See more keywords
Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.107757
Abstract: Summary The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that… read more here.
Keywords: rich motifs; localization; proline rich; phosphorylation ... See more keywords
The proline-rich antimicrobial peptide Api137 is bactericidal in porcine blood infected ex vivo with a porcine or an human Klebsiella pneumoniae strain.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.12.012
Abstract: OBJECTIVES Klebsiella (K.) pneumoniae is an emerging invasive pathogen in humans and pigs. Resistance against multiple antibiotics in this species is a major health concern and development of new antibiotics is urgently needed. The objective… read more here.
Keywords: pneumoniae; blood; rich antimicrobial; porcine blood ... See more keywords
The proline-rich myticalins from Mytilus galloprovincialis display a membrane-permeabilizing antimicrobial mode of action
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2021.170594
Abstract: Bivalve mollusks are continuously exposed to potentially pathogenic microorganisms living in the marine environment. Not surprisingly, these filter-feeders developed a robust innate immunity to protect themselves, which includes a broad panel of antimicrobial peptides. Among… read more here.
Keywords: rich myticalins; proline rich; mytilus galloprovincialis; mode action ... See more keywords