Asymmetric Synthesis of α-Alkylidene-β-Lactams through Copper Catalysis with a Prolinol-Phosphine Chiral Ligand.
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DOI: 10.1021/acs.orglett.9b00276
Abstract: A copper/prolinol-phosphine chiral catalyst enabled the one-step synthesis of chiral α-alkylidene-β-lactams. Optimization of the chiral ligand for steric and electronic properties realized the highly enantioselective coupling of nitrones and propargyl alcohol derived alkynes. The resulting… read more here.
Keywords: phosphine chiral; alkylidene; alkylidene lactams; prolinol phosphine ... See more keywords