Model averaging for robust assessment of QT prolongation by concentration-response analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7395
Abstract: Assessing the QT prolongation potential of a drug is typically done based on pivotal safety studies called thorough QT studies. Model-based estimation of the drug-induced QT prolongation at the estimated mean maximum drug concentration could… read more here.
Keywords: concentration response; model averaging; method; model ... See more keywords
Effect of QTU prolongation on hyperemic instantaneous wave-free ratio value: a prospective single-center study
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DOI: 10.1007/s00380-020-01562-8
Abstract: We hypothesized that in patients with QT prolongation, resistance might not decrease in the wave-free period, because QTU prolongation cannot be detected by instantaneous wave-free ratio (iFR) analysis software. We investigated whether corrected QTU (QTUc)… read more here.
Keywords: administration; value; ifr; hyperemic ifr ... See more keywords
Prolongation of QTc interval at the beginning and during dialysis is associated with hypervolemia and calcium and magnesium change in the first 2 h
Sign Up to like & getrecommendations! Published in 2021 at "International Urology and Nephrology"
DOI: 10.1007/s11255-021-03016-0
Abstract: High rates of sudden cardiac death are mostly attributed to ventricular arrhythmias including QTc prolongation in hemodialysis patients. We aimed to investigate the correlation of electrolyte and volume changes with QTc interval prolongation in hemodialysis… read more here.
Keywords: qtc interval; group; interval beginning; dialysis ... See more keywords
Absence of QTc Prolongation with Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate (SNAC), an Absorption Enhancer Co-Formulated with the GLP-1 Analogue Semaglutide for Oral Administration
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DOI: 10.1007/s13300-021-01106-x
Abstract: Oral delivery of proteins, including glucagon-like peptide 1 (GLP-1) receptor agonists, is impeded by low gastrointestinal permeation. Oral semaglutide has been developed for once-daily oral administration by co-formulation of the GLP-1 analogue semaglutide with an… read more here.
Keywords: trial; part; interval; snac ... See more keywords
Prolongation of the QTc interval in HIV-infected individuals compared to the general population
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DOI: 10.1007/s15010-017-1053-9
Abstract: ObjectivesProlonged QT interval is associated with arrhythmias and sudden death. An increased prevalence of QT interval prolongation in human immunodeficiency virus-infected (HIV) subjects was previously described. The impact of different medications and HIV infection itself… read more here.
Keywords: hiv; prolongation qtc; interval; compared general ... See more keywords
Drug-Induced QT Prolongation and Torsades de Pointes: An All-Exclusive Relationship or Time for an Amicable Separation?
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DOI: 10.1007/s40264-017-0584-4
Abstract: QT prolongation was perceived as a major antiarrhythmic mechanism, but soon became a surrogate for torsades de pointes (TdP) instead. Drugs that prolong the QT interval range from having potent torsadogenic activity to no proarrhythmic… read more here.
Keywords: induced prolongation; torsades pointes; time; drug induced ... See more keywords
Apparently trivial but serious mistakes: the underestimated risk of a QT prolongation
Sign Up to like & getrecommendations! Published in 2018 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-018-0900-6
Abstract: Polypharmacy is very common among older adults and is often associated with adverse drug events and potentially severe drug–drug interactions (DDIs) [1]. Although most DDIs might be prevented or avoided, their lack of recognition is… read more here.
Keywords: drug; day; prolongation; tmp smx ... See more keywords
2-1-102. Changes in corrected QT interval during electroconvulsive therapy
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DOI: 10.1016/j.clinph.2017.03.017
Abstract: Corrected QT interval (QTc) prolongation can trigger ventricular arrhythmia, including torsade de pointes (TdP). A QTc greater than 500 ms is considered to provide a high risk of TdP. Herein, we evaluated the risk of TdP… read more here.
Keywords: qtc prolongation; corrected interval; electroconvulsive therapy; prolongation ... See more keywords
Current perspective: Osimertinib-induced QT prolongation: new drugs with new side-effects need careful patient monitoring.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.12.011
Abstract: An increasing number of tyrosine kinase inhibitors (TKIs) are available for the treatment of non-small cell lung cancer (NSCLC). QT prolongation is one of the known, but relatively rare, adverse events of several TKIs (e.g.… read more here.
Keywords: treatment; monitoring; osimertinib; cancer ... See more keywords
Unusual T-wave changes and extreme QTc prolongation in a 71-year-old man with asymptomatic COVID infection
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DOI: 10.1016/j.hrcr.2021.11.008
Abstract: Introduction The QT interval represents the time between onset of ventricular depolarization (QRS complex) and conclusion of repolarization (terminal T wave), as detected by surface electrocardiogram (ECG). A prolonged corrected QT interval (QTc) is associated… read more here.
Keywords: covid infection; prolongation; qtc; unusual wave ... See more keywords
Impact of acute atrial fibrillation termination and prolongation of atrial fibrillation cycle length on the outcome of ablation of persistent atrial fibrillation: A substudy of the STAR AF II trial.
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DOI: 10.1016/j.hrthm.2016.12.033
Abstract: BACKGROUND Controversy exists about the impact of acute atrial fibrillation (AF) termination and prolongation of atrial fibrillation cycle length (AFCL) during ablation on long-term procedural outcome. OBJECTIVE The purpose of this study was to analyze… read more here.
Keywords: atrial fibrillation; fibrillation; trial; ablation ... See more keywords