Efficient coexpression of recombinant human fusion collagen with prolyl 4âhydroxylase from Bacillus anthracis in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2396
Abstract: Collagen family members, the most abundant proteins in the human body, are widely used in biomedical fields and tissue engineering industries. However, the applications of collagen remain mostly relying on material derived from native tissues… read more here.
Keywords: human fusion; fusion collagen; prolyl; collagen ... See more keywords
Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond.
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DOI: 10.1021/acs.biochem.6b00976
Abstract: Collagen prolyl 4-hydroxylases (CP4Hs) catalyze a prevalent posttranslational modification, the hydroxylation of (2S)-proline residues in protocollagen strands. The ensuing (2S,4R)-4-hydroxyproline residues are necessary for the conformational stability of the collagen triple helix. Prolyl peptide bonds… read more here.
Keywords: prolyl; prolyl peptide; prolyl hydroxylase; peptide bond ... See more keywords
Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316034
Abstract: Supplemental Digital Content is available in the text. Objective: Atherosclerosis is a key component of cardiovascular diseases. We set out to study here whether genetic ablation of P4H-TM (transmembrane prolyl 4-hydroxylase) could protect against atherosclerosis… read more here.
Keywords: genetic ablation; prolyl hydroxylase; prolyl; transmembrane prolyl ... See more keywords