Rational Design of a Highly Specific Prolyl Endopeptidase To Activate the Antihypertensive Effect of Peptides
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200691
Abstract: Enzymatic hydrolysis of food‐derived proteins to produce bioactive peptides could activate food functions such as antihypertension. However, the diversity of enzymatic hydrolysis products can reduce bioactive peptides’ efficacy. Highly specific proteases can homogenize the hydrolysis… read more here.
Keywords: prolyl endopeptidase; bioactive peptides; highly specific; antihypertensive effect ... See more keywords
Chemical constituents from Parrotia persica- Structural derivatization and their potential prolyl endopeptidase inhibition activity.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103526
Abstract: The current study was aimed to evaluate the prolyl endopeptidase (PEP) inhibitory activity of glutinol (1), azadiradione (2), quercetin 3-O-β-d-glactopyranoside (3), catechin (4), quercetin (5), naringenin (6) isolated from Parrotia persica C. A. Mey. Naringenin… read more here.
Keywords: prolyl endopeptidase; inhibition; parrotia persica; inhibition activity ... See more keywords
Characterization and rational design for substrate specificity of a prolyl endopeptidase from Stenotrophomonas maltophilia.
Sign Up to like & getrecommendations! Published in 2020 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2020.109548
Abstract: A novel prolyl endopeptidase from Stenotrophomonas maltophilia, SmPEP, was discovered and characterized. The specific activity of the recombinant SmPEP expressed by Escherichia coli BL21 (DE3), was 68.3 U/mg at pH 8.0 and 37 °C. In order… read more here.
Keywords: prolyl endopeptidase; substrate; endopeptidase stenotrophomonas; substrate specificity ... See more keywords
Effective separation of prolyl endopeptidase from Aspergillus Niger by aqueous two phase system and its characterization and application.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.120
Abstract: Aspergillus niger prolyl endopeptidase (An-PEP) has become a research focus because of its advantages in specifically cleaving the C-terminal peptide bond of proline residues, especially it was an industrial food-grade acidic PEP. Aqueous two-phase system… read more here.
Keywords: aspergillus niger; prolyl endopeptidase; two phase; application ... See more keywords
Degradation Mechanism of Soybean Protein B3 Subunit Catalyzed by Prolyl Endopeptidase from Aspergillus niger during Soy Sauce Fermentation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01796
Abstract: Soy sauce secondary precipitate formed due to the B3 subunit seriously affects soy sauce's appearance quality. In this study, a prolyl endopeptidase (APE) from Aspergillus niger, which could degrade approximately 50% of the B3 subunit… read more here.
Keywords: prolyl endopeptidase; ape; subunit; soy sauce ... See more keywords