Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114899
Abstract: The accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of Parkinson's disease (PD). Several preclinical studies have shown α-syn aggregation, and particularly the… read more here.
Keywords: syn; kyp 2047; chaperone mediated; mediated autophagy ... See more keywords
Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104558
Abstract: Prolyl oligopeptidase (PREP) is a serine protease that has been studied particularly in the context of neurodegenerative diseases for decades but its physiological function has remained unclear. We have previously found that PREP negatively regulates… read more here.
Keywords: prep inhibition; prep; inhibition; prolyl oligopeptidase ... See more keywords
The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2023.2170973
Abstract: Prolyl oligopeptidase (POP) is a conserved serine protease belonging to proline-specific peptidases. It has both enzymatic and non-enzymatic activity and is involved in numerous biological processes in the human body, playing a role in e.g.,… read more here.
Keywords: food; role; food proteins; peptidic inhibitors ... See more keywords
Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Research"
DOI: 10.1080/14786419.2016.1255890
Abstract: Abstract Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and… read more here.
Keywords: prolyl oligopeptidase; acetylcholinesterase; leonurus sibiricus;
Evaluation of prolyl oligopeptidase and acetylcholinesterase inhibition by Phyllanthus tenellus Roxb. from Brazil
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1637869
Abstract: Abstract Phyllanthus tenellus Roxb. (Phyllanthaceae) is a plant used in Brazilian folk medicine for the treatment of intestinal infections and diabetes. Despite its use in traditional medicine, it was reported that P. tenellus extract may… read more here.
Keywords: phyllanthus tenellus; medicine; tenellus roxb; prolyl oligopeptidase ... See more keywords
Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.01060
Abstract: Leishmania infantum is a flagellated protozoan and one of the main causative agents of visceral leishmaniasis. This disease usually affects the human reticuloendothelial system, can cause death and available therapies may lead to serious side… read more here.
Keywords: infantum; prolyl oligopeptidase; macrophage infection; leishmania infantum ... See more keywords
Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076016
Abstract: Cognitive impairment represents one of the core features of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia, although little is known about how POP… read more here.
Keywords: phb2 levels; inhibition; cognitive deficits; prolyl oligopeptidase ... See more keywords