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   Articles with "prolymphocytic leukemia" as a keyword



Delineation of clinical course, outcomes, and prognostic factors in patients with T‐cell prolymphocytic leukemia

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recommendations! Published in 2023 at "American Journal of Hematology"

DOI: 10.1002/ajh.26918

Abstract: T‐cell prolymphocytic leukemia (T‐PLL) is a rare, post‐thymic T‐cell neoplasm with a diverse clinical course. T‐PLL is typically associated with a poor prognosis; however, a subset of patients have inactive disease on initial presentation. There… read more here.

Keywords: prognostic factors; disease; clinical course; course ... See more keywords
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GvL effects in T-prolymphocytic leukemia: evidence from MRD kinetics and TCR repertoire analyses

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recommendations! Published in 2017 at "Bone Marrow Transplantation"

DOI: 10.1038/bmt.2016.305

Abstract: Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-prolymphocytic leukemia (T-PLL). However, direct evidence of GvL activity in T-PLL is lacking. We correlated minimal residual disease (MRD) kinetics with immune interventions and… read more here.

Keywords: mrd; mrd kinetics; evidence; prolymphocytic leukemia ... See more keywords

Morphology, immunophenotype, and suggested diagnostic criteria of TCL1 family-negative T-prolymphocytic leukemia.

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recommendations! Published in 2024 at "American journal of clinical pathology"

DOI: 10.1093/ajcp/aqae075

Abstract: OBJECTIVES We sought to investigate the morphologic and immunophenotypic characteristics of TCL1 family-negative T-cell prolymphocytic leukemia (T-PLL). METHODS Twenty cases of TCL1 family-negative T-PLL were studied. RESULTS The doubling time of leukemic cells ranged from… read more here.

Keywords: immunophenotypic; tcl1 family; pll; prolymphocytic leukemia ... See more keywords

CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up.

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recommendations! Published in 2019 at "American journal of clinical pathology"

DOI: 10.1093/ajcp/aqz060

Abstract: OBJECTIVES CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in… read more here.

Keywords: cd161; disease; cell prolymphocytic; prolymphocytic leukemia ... See more keywords

Comparison of clinicopathological characteristics between T‐cell prolymphocytic leukemia and peripheral T‐cell lymphoma, not otherwise specified

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recommendations! Published in 2017 at "European Journal of Haematology"

DOI: 10.1111/ejh.12856

Abstract: T‐cell prolymphocytic leukemia (T‐PLL) is a very rare, aggressive T‐cell neoplasm. Peripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore,… read more here.

Keywords: lymphoma; cell prolymphocytic; prolymphocytic leukemia; cell ... See more keywords

Mutations in PIGA cause a CD52‐/GPI‐anchor‐deficient phenotype complicating alemtuzumab treatment in T‐cell prolymphocytic leukemia

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recommendations! Published in 2020 at "European Journal of Haematology"

DOI: 10.1111/ejh.13511

Abstract: Infusional alemtuzumab followed by consolidating allogeneic hematopoietic stem cell transplantation in eligible patients is considered a standard of care in T‐cell prolymphocytic leukemia (T‐PLL). Antibody selection against CD52 has been associated with the development of… read more here.

Keywords: cd52; cell prolymphocytic; mutations piga; prolymphocytic leukemia ... See more keywords

Generalized pruritic dark papules in a patient with T‐cell prolymphocytic leukemia – a clinicopathological challenge

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recommendations! Published in 2019 at "International Journal of Dermatology"

DOI: 10.1111/ijd.14642

Abstract: A 48-year-old man presented with multiple pruritic dark red papules for 9 months. The lesions started on his hands and subsequently spread to the trunk and limbs within the last 2 months. He also had… read more here.

Keywords: pruritic dark; blood; cell prolymphocytic; prolymphocytic leukemia ... See more keywords

Relapsed B‐cell prolymphocytic leukemia (B‐PLL) with distinctive granular inclusion bodies

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recommendations! Published in 2024 at "International Journal of Laboratory Hematology"

DOI: 10.1111/ijlh.14237

Abstract: The typical morphological features of B-cell prolymphocytic leukemia (B-PLL) include a single vesicular nucleolus, condensed chromatin devoid of granules. In this case, we highlight a rare instance of relapsed B-PLL with distinctive granular inclusion bodies.… read more here.

Keywords: distinctive granular; pll; pll distinctive; prolymphocytic leukemia ... See more keywords

Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia.

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recommendations! Published in 2022 at "Cancer research"

DOI: 10.1158/0008-5472.can-21-1908

Abstract: T-cell prolymphocytic leukemia (T-PLL) is a chemotherapy-refractory T-cell malignancy with limited therapeutic options and a poor prognosis. Current disease concepts implicate TCL1A oncogene-mediated enhanced T-cell receptor (TCR) signaling and aberrant DNA repair as central perturbed… read more here.

Keywords: cell; ago2; non canonical; cell prolymphocytic ... See more keywords

Recurrence of T-Cell Prolymphocytic Leukemia With a Rare Presentation as Diffuse Generalized Skin Lesion

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recommendations! Published in 2023 at "Journal of Investigative Medicine High Impact Case Reports"

DOI: 10.1177/23247096231176223

Abstract: T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm that originates from mature post-thymic T-cells. Cutaneous manifestations are a common presentation in T-PLL but rarely are a presentation in the recurrent setting. Here, we… read more here.

Keywords: prolymphocytic leukemia; pll; cell prolymphocytic; diffuse ... See more keywords
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T-cell prolymphocytic leukemia negative for surface CD3 and CD45.

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-03-840611

Abstract: ![Figure][1] A 75-year-old man was referred to us with an outside diagnosis of T-cell prolymphocytic leukemia (T-PLL) posttreatment. He had mild leukocytosis (white blood cell count, 11.5 × 109/L) and multicompartmental lymphadenopathy by positron emission… read more here.

Keywords: cell; negative surface; cell prolymphocytic; prolymphocytic leukemia ... See more keywords