Rationalizing Promiscuity Cliffs
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700535
Abstract: Compound promiscuity can be viewed in different ways. We distinguish “bad” promiscuity resulting from chemical liabilities, nonspecific binding, or assay artifacts, from “good” promiscuity representing true multitarget activities. Investigating multitarget activities of small molecules is… read more here.
Keywords: rationalizing promiscuity; multitarget activities; promiscuity; promiscuity cliffs ... See more keywords
Promiscuity and sex ratio in the terrestrial isopod Armadillidium vulgare and consequences on genetic diversity
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Processes"
DOI: 10.1016/j.beproc.2019.104030
Abstract: In promiscuous mating systems, both males and females mate with several partners. While the benefits of multiple mating are well recognized for males, there are several non-mutually exclusive hypotheses to explain multiple mating for females.… read more here.
Keywords: sex ratio; genetic diversity; isopod armadillidium; armadillidium vulgare ... See more keywords
Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.02.021
Abstract: The view of enzymes as punctilious catalysts has been shifting as examples of their promiscuous behavior increase. However, unlike a number of cases where the physiological relevance of breached substrate specificity is questionable, the very… read more here.
Keywords: promiscuity; promiscuity heme; catalytic promiscuity; synthesis ... See more keywords
Substrate promiscuity of a de novo designed peroxidase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111370
Abstract: The design and construction of de novo enzymes offer potentially facile routes to exploiting powerful chemistries in robust, expressible and customisable protein frameworks, while providing insight into natural enzyme function. To this end, we have… read more here.
Keywords: substrate promiscuity; peroxidase; promiscuity; promiscuity novo ... See more keywords
Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b02211
Abstract: Metallodrug-protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with proteins are… read more here.
Keywords: protein; protein interactions; metallodrug protein; tool ... See more keywords
Evaluating the Utility of the MSTI Assay in Predicting Compound Promiscuity and Cytotoxicity.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00243
Abstract: Nonspecific reactive chemicals often interfere with the interpretation of high-throughput assay results because of their promiscuity and/or cytotoxicity. Using a high-throughput assay to identify such compounds is necessary to efficiently rule out potential assay artifacts.… read more here.
Keywords: promiscuity cytotoxicity; promiscuity; compound promiscuity; msti assay ... See more keywords
Understanding the Enzyme (S)‑Norcoclaurine Synthase Promiscuity to Aldehydes and Ketones
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.3c01773
Abstract: The (S)-norcoclaurine synthase from (TfNCS) stereoselectively catalyzes the Pictet–Spengler reaction between dopamine and 4-hydroxyphenylacetaldehyde to give (S)-norcoclaurine. TfNCS can catalyze the Pictet–Spengler reaction with various aldehydes and ketones, leading to diverse tetrahydroisoquinolines. This substrate promiscuity… read more here.
Keywords: norcoclaurine synthase; understanding enzyme; promiscuity; pictet spengler ... See more keywords
Substrate Promiscuity of the Triceptide Maturase XncB Leads to Incorporation of Various Amino Acids and Detection of Oxygenated Products.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00782
Abstract: Triceptides are cyclophane-containing ribosomally synthesized and post-translationally modified peptides. The characteristic cross-links are formed between an aromatic ring to Cβ on three-residue Ω1X2X3 motifs (Ω1 = aromatic). Here, we explored the promiscuity of the XYE… read more here.
Keywords: xncb; promiscuity; amino acids; maturase xncb ... See more keywords
Elucidating Substrate Promiscuity within the FabI Enzyme Family.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00400
Abstract: The rapidly growing appreciation of enzymes' catalytic and substrate promiscuity may lead to their expanded use in the fields of chemical synthesis and industrial biotechnology. Here, we explore the substrate promiscuity of enoyl-acyl carrier protein… read more here.
Keywords: substrate promiscuity; within fabi; promiscuity; elucidating substrate ... See more keywords
Determinants and Prediction of Esterase Substrate Promiscuity Patterns.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00996
Abstract: Esterases receive special attention because of their wide distribution in biological systems and environments and their importance for physiology and chemical synthesis. The prediction of esterases' substrate promiscuity level from sequence data and the molecular… read more here.
Keywords: substrate promiscuity; sequence data; promiscuity; prediction ... See more keywords
Modulation of Catalytic Promiscuity during Hydrogen Sulfide Oxidation.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00258
Abstract: The mitochondrial sulfide oxidation pathway prevents the toxic accumulation of hydrogen sulfide (H2S), a signaling molecule that is maintained at low steady-state concentrations. Sulfide quinone oxidoreductase (SQR), an inner mitochondrial membrane-anchored protein, catalyzes the first… read more here.
Keywords: sulfide oxidation; modulation catalytic; oxidation; promiscuity ... See more keywords