Rationalizing Promiscuity Cliffs
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700535
Abstract: Compound promiscuity can be viewed in different ways. We distinguish “bad” promiscuity resulting from chemical liabilities, nonspecific binding, or assay artifacts, from “good” promiscuity representing true multitarget activities. Investigating multitarget activities of small molecules is… read more here.
Keywords: rationalizing promiscuity; multitarget activities; promiscuity; promiscuity cliffs ... See more keywords
Promiscuity and sex ratio in the terrestrial isopod Armadillidium vulgare and consequences on genetic diversity
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Processes"
DOI: 10.1016/j.beproc.2019.104030
Abstract: In promiscuous mating systems, both males and females mate with several partners. While the benefits of multiple mating are well recognized for males, there are several non-mutually exclusive hypotheses to explain multiple mating for females.… read more here.
Keywords: sex ratio; genetic diversity; isopod armadillidium; armadillidium vulgare ... See more keywords
Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.02.021
Abstract: The view of enzymes as punctilious catalysts has been shifting as examples of their promiscuous behavior increase. However, unlike a number of cases where the physiological relevance of breached substrate specificity is questionable, the very… read more here.
Keywords: promiscuity; promiscuity heme; catalytic promiscuity; synthesis ... See more keywords
Substrate promiscuity of a de novo designed peroxidase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111370
Abstract: The design and construction of de novo enzymes offer potentially facile routes to exploiting powerful chemistries in robust, expressible and customisable protein frameworks, while providing insight into natural enzyme function. To this end, we have… read more here.
Keywords: substrate promiscuity; peroxidase; promiscuity; promiscuity novo ... See more keywords
Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b02211
Abstract: Metallodrug-protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with proteins are… read more here.
Keywords: protein; protein interactions; metallodrug protein; tool ... See more keywords
Elucidating Substrate Promiscuity within the FabI Enzyme Family.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00400
Abstract: The rapidly growing appreciation of enzymes' catalytic and substrate promiscuity may lead to their expanded use in the fields of chemical synthesis and industrial biotechnology. Here, we explore the substrate promiscuity of enoyl-acyl carrier protein… read more here.
Keywords: substrate promiscuity; within fabi; promiscuity; elucidating substrate ... See more keywords
Determinants and Prediction of Esterase Substrate Promiscuity Patterns.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00996
Abstract: Esterases receive special attention because of their wide distribution in biological systems and environments and their importance for physiology and chemical synthesis. The prediction of esterases' substrate promiscuity level from sequence data and the molecular… read more here.
Keywords: substrate promiscuity; sequence data; promiscuity; prediction ... See more keywords
Modulation of Catalytic Promiscuity during Hydrogen Sulfide Oxidation.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00258
Abstract: The mitochondrial sulfide oxidation pathway prevents the toxic accumulation of hydrogen sulfide (H2S), a signaling molecule that is maintained at low steady-state concentrations. Sulfide quinone oxidoreductase (SQR), an inner mitochondrial membrane-anchored protein, catalyzes the first… read more here.
Keywords: sulfide oxidation; modulation catalytic; oxidation; promiscuity ... See more keywords
Promiscuity Characteristics of Versatile Plant Glycosyltransferases for Natural Product Glycodiversification.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00489
Abstract: Glycodiversification can optimize the properties of pharmaceutical compounds, and versatile glycosyltransferases (GTs) are the key enzymatic toolkits to achieve this goal. Plant GTs in the GT1 family (GT1-pGTs) have attracted much attention due to their… read more here.
Keywords: glycodiversification; promiscuity; gt1 pgts; plant ... See more keywords
The importance of catalytic promiscuity for enzyme design and evolution
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Chemistry"
DOI: 10.1038/s41570-019-0143-x
Abstract: The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely played a crucial role in organisms’ abilities to adapt to changing external stimuli in the past and can still be observed in extant… read more here.
Keywords: importance catalytic; evolution; enzyme design; promiscuity ... See more keywords
Promiscuity and specificity of eukaryotic glycosyltransferases
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190651
Abstract: Glycosyltransferases are a large family of enzymes responsible for covalently linking sugar monosaccharides to a variety of organic substrates. These enzymes drive the synthesis of complex oligosaccharides known as glycans, which play key roles in… read more here.
Keywords: synthesis; promiscuity; promiscuity specificity; eukaryotic glycosyltransferases ... See more keywords