LAUSR

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

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1 Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-33328-8

Abstract: ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling small changes in cytosolic Ca2+ to trigger large changes in channel activity. With recent landmark determinations of the full structures of RyR1 (skeletal… read more here.

Keywords: binding site; ryr2; atp binding; promiscuous attraction ... See more keywords