PRMT5: A Promising Synthetical Lethal Target for MTAP-Deleted Cancers.
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DOI: 10.1021/acs.jmedchem.5c01895
Abstract: PRMT5 is a promising target for cancer therapy. However, the first-generation PRMT5 inhibitors failed in the clinical trials due to the dose-limiting hematological toxicities, which could be attributed to the indiscriminate blockade of PRMT5 and… read more here.
Keywords: prmt5 promising; lethal; promising synthetical; target ... See more keywords