NSD3: A Promising Target for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70071
Abstract: Over the past 24 years, nuclear receptor‐binding SET domain protein 3 (NSD3) has emerged as a critical regulator of cellular physiological processes. As a histone methyltransferase targeting H3K36, NSD3 catalyzes the addition of methyl groups… read more here.
Keywords: cancer; target cancer; nsd3 promising; promising target ... See more keywords
CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06215-1
Abstract: Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a… read more here.
Keywords: crebbp; promising target; expression; gene ... See more keywords
Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt01350g
Abstract: CpsB is a metal ion-dependent hydrolase involved in the biosynthesis of capsular polysaccharides in bacterial organisms. The enzyme has been proposed as a promising target for novel chemotherapeutics to combat antibiotic resistance. The crystal structure… read more here.
Keywords: metallohydrolase; promising target; target novel; cpsb ... See more keywords
Aminopeptidase N: a multifunctional and promising target in medicinal chemistry
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra03038b
Abstract: Aminopeptidase N (APN) is a zinc metalloproteinase present in almost all types of organisms and has various functions. Many of them are unrelated to its catalytic activity, which is why APN is sometimes classified as… read more here.
Keywords: chemistry; multifunctional promising; aminopeptidase multifunctional; promising target ... See more keywords
A promising target for breast cancer: B7-H3
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-11933-3
Abstract: Breast cancer (BC) is the second-leading factor of mortality for women globally and is brought on by a variety of genetic and environmental causes. The conventional treatments for this disease have limitations, making it difficult… read more here.
Keywords: promising target; cancer; breast cancer; cancer promising ... See more keywords
Translocator Protein 18-kDa: a promising target to treat neuroinflammation-related degenerative diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220415120820
Abstract: In the nervous system, inflammatory responses physiologically occur as defense mechanisms triggered by damaging events. If improperly regulated, neuroinflammation can contribute to the development of chronically activated states of glial cells, with the perpetuation of… read more here.
Keywords: neuroinflammation; translocator protein; promising target; neuroinflammation related ... See more keywords
CYP1B1: a Promising Target in Cancer Drug Discovery.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230119103914
Abstract: CYP1B1 plays an essential role in cancer's pathogenesis since it activates procarcinogens. Significantly, this enzyme catalyzes the hydroxylation of 17β-estradiol, leading to carcinogenic metabolites involved in carcinogenesis and cancer progression. Therefore, the inhibition of CYP1B1… read more here.
Keywords: promising target; cyp1b1; cyp1b1 promising; drug ... See more keywords
Dickkopf-1: A Promising Target for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.658097
Abstract: Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated with a poor prognosis. Our analysis… read more here.
Keywords: promising target; dkk1; target cancer; cancer immunotherapy ... See more keywords
Can G-quadruplex become a promising target in HBV therapy?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1091873
Abstract: The chronic infection with hepatitis B virus (HBV) is an important health problem that affects millions of people worldwide. Current therapies for HBV always suffer from a poor response rate, common side effects, and the… read more here.
Keywords: hbv; become promising; promising target; therapy ... See more keywords
The role of TIM-3 in sepsis: a promising target for immunotherapy?
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1328667
Abstract: Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders.… read more here.
Keywords: role tim; tim sepsis; promising target; tim ... See more keywords
FPR2: A Novel Promising Target for the Treatment of Influenza
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.01719
Abstract: The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit.… read more here.
Keywords: promising target; novel promising; target; target treatment ... See more keywords