CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06215-1
Abstract: Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a… read more here.
Keywords: crebbp; promising target; expression; gene ... See more keywords
Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt01350g
Abstract: CpsB is a metal ion-dependent hydrolase involved in the biosynthesis of capsular polysaccharides in bacterial organisms. The enzyme has been proposed as a promising target for novel chemotherapeutics to combat antibiotic resistance. The crystal structure… read more here.
Keywords: metallohydrolase; promising target; target novel; cpsb ... See more keywords
Translocator Protein 18-kDa: a promising target to treat neuroinflammation-related degenerative diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220415120820
Abstract: In the nervous system, inflammatory responses physiologically occur as defense mechanisms triggered by damaging events. If improperly regulated, neuroinflammation can contribute to the development of chronically activated states of glial cells, with the perpetuation of… read more here.
Keywords: neuroinflammation; translocator protein; promising target; neuroinflammation related ... See more keywords
CYP1B1: a Promising Target in Cancer Drug Discovery.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230119103914
Abstract: CYP1B1 plays an essential role in cancer's pathogenesis since it activates procarcinogens. Significantly, this enzyme catalyzes the hydroxylation of 17β-estradiol, leading to carcinogenic metabolites involved in carcinogenesis and cancer progression. Therefore, the inhibition of CYP1B1… read more here.
Keywords: promising target; cyp1b1; cyp1b1 promising; drug ... See more keywords
Dickkopf-1: A Promising Target for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.658097
Abstract: Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated with a poor prognosis. Our analysis… read more here.
Keywords: promising target; dkk1; target cancer; cancer immunotherapy ... See more keywords
Can G-quadruplex become a promising target in HBV therapy?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1091873
Abstract: The chronic infection with hepatitis B virus (HBV) is an important health problem that affects millions of people worldwide. Current therapies for HBV always suffer from a poor response rate, common side effects, and the… read more here.
Keywords: hbv; become promising; promising target; therapy ... See more keywords
FPR2: A Novel Promising Target for the Treatment of Influenza
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.01719
Abstract: The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit.… read more here.
Keywords: promising target; novel promising; target; target treatment ... See more keywords
Will Sirtuin 2 Be a Promising Target for Neuroinflammatory Disorders?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.915587
Abstract: Neuroinflammatory disorder is a general term that is associated with the progressive loss of neuronal structure or function. At present, the widely studied diseases with neuroinflammatory components are mainly divided into neurodegenerative and neuropsychiatric diseases,… read more here.
Keywords: sirtuin promising; neuroinflammatory disorders; promising target; immune homeostasis ... See more keywords
Astrocyte, a Promising Target for Mood Disorder Interventions
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00136
Abstract: Mood disorders have multiple phenotypes and complex underlying biological mechanisms and, as such, there are no effective therapeutic strategies. A review of recent work on the role of astrocytes in mood disorders is thus warranted,… read more here.
Keywords: promising target; role astrocytes; astrocyte promising; mood disorders ... See more keywords
TIGIT: A promising target to overcome the barrier of immunotherapy in hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1091782
Abstract: Immune evasion through up-regulating checkpoint inhibitory receptors on T cells plays an essential role in tumor initiation and progression. Therefore, immunotherapy, including immune checkpoint inhibitor targeting programmed cell death protein 1 (PD-1) and chimeric antigen… read more here.
Keywords: overcome barrier; promising target; target overcome; hematological malignancies ... See more keywords
Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051226
Abstract: The authors wish to make the following corrections to this paper [...]. read more here.
Keywords: benelli aspartate; promising target; aspartate hydroxylase; erratum benelli ... See more keywords