Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.12.040
Abstract: It was postulated that neuropeptide Y (NPY)-ergic system could be involved in the ischemic pathophysiology, however, the role of particular subtypes of NPY receptors (YRs) in neuroprotection against ischemia is still not well known. Therefore,… read more here.
Keywords: promising targets; glucose deprivation; targets neuroprotection; ischemia ... See more keywords
Aldehyde Dehydrogenases as Promising Targets for Treating Toxic Alde-hyde-related Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230408200401
Abstract: Background: Mammals are exposed to various endogenous and exogenous aldehydes, and aldehyde dehydrogenases (ALDHs) function to metabolize these aldehydes to acids to counteract aldehyde over-load. ALDHs therefore play important roles in a series of physiological… read more here.
Keywords: promising targets; aldehyde related; aldehyde dehydrogenases; toxic aldehyde ... See more keywords
Which are the most promising targets for minimal residual disease-directed therapy in acute myeloid leukemia prior to allogeneic stem cell transplant?
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.208587
Abstract: Minimal residual disease has emerged as an important prognostic factor for relapse and survival in acute myeloid leukemia. Eradication of minimal residual disease may increase the number of patients with long-term survival; however, to date,… read more here.
Keywords: promising targets; minimal residual; myeloid leukemia; residual disease ... See more keywords
Chemokines and chemokine receptors as promising targets in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1100869
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play important roles in RA development and pathogenesis. Biological therapies targeting… read more here.
Keywords: promising targets; receptors promising; chemokines chemokine; rheumatoid arthritis ... See more keywords
G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
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DOI: 10.3390/biom12050648
Abstract: G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill important genome… read more here.
Keywords: quadruplex binding; promising targets; targets drug; binding proteins ... See more keywords
New Promising Targets for Synthetic Omptin-Based Peptide Vaccine against Gram-Negative Pathogens
Sign Up to like & getrecommendations! Published in 2019 at "Vaccines"
DOI: 10.3390/vaccines7020036
Abstract: Omptins represent a family of proteases commonly found in various Gram-negative pathogens. These proteins play an important role in host–pathogen interaction and have been recognized as key virulence factors, highlighting the possibility of developing an… read more here.
Keywords: promising targets; gram negative; targets synthetic; new promising ... See more keywords