Antiviral peptides as promising therapeutic drugs
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03138-w
Abstract: While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence… read more here.
Keywords: antiviral peptides; therapeutic drugs; peptides promising; antimicrobial peptides ... See more keywords
Pentraxin 3: A promising therapeutic target for autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2020.102584
Abstract: Pentraxin 3 (PTX3) is a prototypic humoral soluble pattern recognition molecule that exerts a pivotal role in innate immune response and inflammation, as well as in tissue damage and remodeling. Recently, emerging evidence has revealed… read more here.
Keywords: autoimmune; autoimmune diseases; promising therapeutic; therapeutic target ... See more keywords
Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2020.114225
Abstract: In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due to a new Coronavirus strain (i.e., SARS-CoV2), emerged in the continental Chinese area of Wuhan and quickly… read more here.
Keywords: proteolytic enzymes; role proteolytic; host; enzymes covid ... See more keywords
B7-H3: A promising therapeutic target for autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104077
Abstract: B7-H3 as a newly identified costimulatory molecule that belongs to B7 ligand family, is broadly expressed in both lymphoid and non-lymphoid tissues. The overexpression of B7-H3 has been verified to be correlated with the poor… read more here.
Keywords: autoimmune; immunology; autoimmune diseases; target autoimmune ... See more keywords
The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e08354
Abstract: The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology. Therefore,… read more here.
Keywords: p38 mapk; mapk signaling; therapeutic potentials; promising therapeutic ... See more keywords
Shikonin, a promising therapeutic drug for osteoarthritis that acts via autophagy activation.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108563
Abstract: Osteoarthritis (OA) is a chronic joint degenerative disease characterised by narrowed articular space, formation of surrounding osteophytes, and subchondral bone sclerosis. OA is caused by cartilage degeneration, which is closely correlated with the disequilibrium of… read more here.
Keywords: shikonin treatment; promising therapeutic; autophagy; osteoarthritis ... See more keywords
Glia-derived exosomes: Promising therapeutic targets.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116951
Abstract: Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells,… read more here.
Keywords: glia derived; therapeutic targets; disease; promising therapeutic ... See more keywords
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77735-2
Abstract: Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage… read more here.
Keywords: post traumatic; therapeutic agent; traumatic osteoarthritis; ptoa ... See more keywords
Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111643118
Abstract: Significance The Keap1-Nrf2 signaling pathway is a promising therapeutic target for Parkinson’s disease (PD). Canonical Nrf2 activators targeting Keap1 thiols are known to be preventive but never effectively cure chronic neurodegeneration because of their electrophilic… read more here.
Keywords: inhibitor; promising therapeutic; bach1; parkinson disease ... See more keywords
Current and promising therapeutic options for Dravet syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2127089
Abstract: ABSTRACT Introduction Dravet Syndrome (DS) is a developmental and epileptic encephalopathy carrying high-level psychobehavioral burdens. Although the disease has been known for almost 4 decades, and despite significant progress in the understanding of its physiopathology… read more here.
Keywords: promising therapeutic; current promising; dravet syndrome; therapeutic options ... See more keywords
Oxytocin receptor is a promising therapeutic target of malignant mesothelioma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15025
Abstract: Malignant mesothelioma (MM) is one of the most aggressive tumors. We conducted bioinformatics analysis using Cancer Cell Line Encyclopedia (CCLE) datasets to identify new molecular markers in MM. Overexpression of oxytocin receptor (OXTR), which is… read more here.
Keywords: promising therapeutic; expression; receptor; cell ... See more keywords