Optimal adaptive promising zone designs
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9339
Abstract: We develop optimal decision rules for sample size re‐estimation in two‐stage adaptive group sequential clinical trials. It is usual for the initial sample size specification of such trials to be adequate to detect a realistic… read more here.
Keywords: sample size; power; zone designs; zone ... See more keywords
Promising zone two-stage design for a single-arm study with binary outcome.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231164737
Abstract: Adaptive designs are increasingly used in clinical trials to assess the effectiveness of new drugs. For a single-arm study with a binary outcome, several adaptive designs were developed by using numerical search algorithms and the… read more here.
Keywords: study binary; single arm; adaptive designs; design ... See more keywords