Abstract 2156: IL-18 pathway agonism expands intratumoral PD1+ Tcf1+ stem-like CD8+ cells and their polyfunctional effector progeny to promote anti-tumor immunity
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DOI: 10.1158/1538-7445.am2020-2156
Abstract: Recombinant cytokines were the first modern immunotherapies to produce durable cures in metastatic cancer, but their application has been hampered by only modest efficacy and limited tolerability. A major limitation to cytokine therapies is their… read more here.
Keywords: cd8 cells; promote anti; anti tumor; effector ... See more keywords
Niloticin binds to MD-2 to promote anti-inflammatory pathway activation in macrophage cells
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DOI: 10.1177/03946320221133017
Abstract: Objectives Niloticin is an active compound isolated from Cortex phellodendri with uncharacterized anti-inflammatory activity. We assessed the drug potential of niloticin and examined its ability to target myeloid differentiation protein 2 (MD-2) to ascertain the… read more here.
Keywords: inflammatory pathway; pharmacology; anti inflammatory; niloticin binds ... See more keywords