Two Complementary Cyclization Reactions for the Chemoselective Synthesis of Spirooxindoles
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201701413
Abstract: Two complementary cascade cyclization reactions were described, namely KHSO4-promoted [1+2+3] cyclization and TMSCl-promoted four-molecular cascade cyclization for the concise synthesis of highly functionalized spirooxindoles in excellent yields. Between them, the improved TMSCl-promoted cyclization reaction of… read more here.
Keywords: promoted cyclization; two complementary; cyclization; cyclization reactions ... See more keywords
Acid-Promoted Cyclization of α-Azidobenzyl Ketones through C═N Bond Formation: Synthesis of 6-Substituted Quinoline Derivatives.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.3c03697
Abstract: An acid-promoted cyclization of α-azidobenzyl ketones has been developed for the synthesis of 6-substituted quinoline derivatives. A variety of synthetically useful 6-OTf or -OMs quinoline derivatives were obtained in moderate to good yields. The reaction… read more here.
Keywords: azidobenzyl ketones; promoted cyclization; acid promoted; cyclization azidobenzyl ... See more keywords
Synthesis of 3H-Pyrrolo[2,3-c]quinoline by Sequential I2-Promoted Cyclization/Staudinger/Aza-Wittig/Dehydroaromatization Reaction
Sign Up to like & getrecommendations! Published in 2019 at "Synlett"
DOI: 10.1055/s-0037-1610688
Abstract: A facile synthetic approach to access of 3H-pyrrolo[2,3-c]quinoline derivatives has been achieved by a sequential I2-promoted cyclization/Staudinger/aza-Wittig/dehydroaromatization reaction. The targeted products were received in moderate to good yields (62–81%). The broad substrate scope and easy… read more here.
Keywords: pyrrolo quinoline; sequential promoted; staudinger aza; cyclization staudinger ... See more keywords
Entry to new spiroheterocycles via tandem Rh(II)-catalyzed O–H insertion/base-promoted cyclization involving diazoarylidene succinimides
Sign Up to like & getrecommendations! Published in 2024 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.20.48
Abstract: A facile approach to novel medicinally relevant spiro heterocyclic scaffolds (namely furan-2(5H)-ones, tetrahydrofurans and pyrans spiro-conjugated with the succinimide ring) has been developed. The protocol consists of Rh(II)-catalyzed insertion of heterocyclic carbenes derived from diazoarylidene… read more here.
Keywords: base promoted; diazoarylidene succinimides; promoted cyclization; catalyzed insertion ... See more keywords