I2-DMSO Promoted Deaminative Coupling Reactions of Glycine Esters: Access to 5-(Methylthio)pyridazin-3(2H)-ones.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00306
Abstract: An unprecedented, one-step strategy for the synthesis of 5-(methylthio)pyridazin-3(2H)-one derivatives has been developed through iodine triggered deaminative coupling of glycine esters with methyl ketones and hydrazine hydrate in DMSO. These transformations in the absence of… read more here.
Keywords: dmso promoted; methylthio pyridazin; glycine esters; promoted deaminative ... See more keywords
Visible light promoted deaminative difluoroalkylation of aliphatic amines with difluoroenoxysilanes.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05725h
Abstract: A visible light promoted deaminative strategy for the difluoroalkylation reaction utilizing pyridinium-activated aliphatic primary amines and difluoroenoxysilane as substrates has been developed. This protocol is characteriazed by its mild reaction conditions and broad substrate scope,… read more here.
Keywords: visible light; promoted deaminative; deaminative difluoroalkylation; difluoroalkylation aliphatic ... See more keywords