Base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO toward 2,4,6-triaryl pyrimidines
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DOI: 10.1016/j.tetlet.2017.11.020
Abstract: Abstract A base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO was developed, leading to a series of 2,4,6-triaryl pyrimidines in moderate to good yields. Notably, DMSO served as a methine source, which was… read more here.
Keywords: aldehyde benzyl; promoted formal; formal annulation; benzyl amidine ... See more keywords
Base-Promoted Formal [3 + 2] Cycloaddition of α-Halohydroxamates with Carbon Disulfide to Synthesize Polysubstituted Rhodanines.
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DOI: 10.1021/acs.orglett.2c00736
Abstract: A concise and practical strategy via potassium-carbonate-mediated [3 + 2]-cycloaddition reaction of α-halohydroxamates with the common solvent carbon disulfide for the synthesis of functionalized rhodanine derivatives in good to excellent yields is developed. The present… read more here.
Keywords: base promoted; promoted formal; carbon disulfide; cycloaddition halohydroxamates ... See more keywords
I2-Promoted formal [3+2] cycloaddition of α-methylenyl isocyanides with methyl ketones: a route to 2,5-disubstituted oxazoles.
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DOI: 10.1039/c6cc10275a
Abstract: An I2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving the C[triple bond, length as… read more here.
Keywords: methyl ketones; cycloaddition methylenyl; promoted formal; formal cycloaddition ... See more keywords