Base-Promoted Ring Expansion Reaction of 4-Quinolones To Access Benzazepinones.
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DOI: 10.1021/acs.orglett.4c03016
Abstract: 4-Quinolone derivatives undergo an unexpected ring expansion reaction with α-halo esters/phosphonates/sulfones in the presence of a base, such as NaH, to produce novel benzazepinones. Under these mild and transition-metal-free conditions, most substrates gave moderate to… read more here.
Keywords: reaction; expansion reaction; base promoted; promoted ring ... See more keywords
FeCl3-Promoted ring size-dictating diversity-oriented synthesis (DOS) of N-heterocycles using in situ-generated cyclic imines and enamines.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03375k
Abstract: The FeCl3-promoted ring size-controlled oxidative activation of o-alkynylanilines opens up a complementary appealing protocol for poly-N-heterocycle synthesis. When electron-poor π-alkyne iron species combine with cyclic enamines obtained from cyclohexanone and β-tetralone, they undergo a regioselective… read more here.
Keywords: size dictating; ring size; promoted ring; fecl3 promoted ... See more keywords
Formation of β-cyano-ketones through cyanide-promoted ring-opening of cyclic organic carbonates
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DOI: 10.1039/d1qo00770j
Abstract: In an unusual cascade process involving KCN, vinyl cyclic carbonates are converted into β-cyano ketones with the subsequent extrusion of carbon dioxide and acetonitrile facilitating a Michael addition to an intermediate α,β-unsaturated ketone. read more here.
Keywords: cyano ketones; ketones cyanide; formation cyano; promoted ring ... See more keywords
Synthesis of [4.6] Spirocarbocycles: A Base-promoted Ring-Expansion and Subsequent I2-mediated Regioselective Spirocyclization Protocol
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DOI: 10.1039/d4qo01632g
Abstract: An efficient protocol for the synthesis of [4.6] spirocarbocycles has been developed. This process is realized through the sequential K2CO3-promoted C−C σ-bond cleavage of cyclic ketoesters and an I2-mediated selective... read more here.
Keywords: synthesis spirocarbocycles; spirocarbocycles base; protocol; promoted ring ... See more keywords