Photoredox-Promoted Selective Synthesis of C-5 Thiolated 2-Aminothiazoles from Terminal Alkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03064
Abstract: A mild photoredox approach enabling the first one-step synthesis of thiolated 2-aminothiazoles has been reported. Notably, the incorporation of thio group on electron-rich heteroarenes such as aminothiazoles via conventional nucleophilic aromatic substitution (SNAr) presents a… read more here.
Keywords: selective synthesis; photoredox promoted; synthesis thiolated; promoted selective ... See more keywords
Visible-Light-Promoted Selective Sulfonylation and Selenylation of Dienes to Access Sulfonyl-/Seleno-benzazepine Derivatives.
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DOI: 10.1021/acs.orglett.3c01550
Abstract: A novel visible-light-promoted selective sulfonylation and selenylation of dienes with selenosulfonates has been developed. This technology provides mild access to a wide range of sulfonyl benzo[b]azepinones and seleno-benzo[b]azepines. Preliminary mechanistic studies suggest that the sulfonylation… read more here.
Keywords: sulfonylation; light promoted; selenylation; selective sulfonylation ... See more keywords
Base-Promoted Selective Synthesis of 2H-Pyranones and Tetrahydronaphthalenes via Domino Reactions
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DOI: 10.1021/acsomega.7b00627
Abstract: A highly efficient domino protocol has been developed for the synthesis of 6-aryl-4-(methylthio/amine-1-yl)-2-oxo-2H-pyran-3-carbonitriles and 4-aryl-2-(amine-1-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitriles from simple and readily available α-aroylketene dithioacetals, malononitrile, secondary amines, and cyclohexanone. This elegant domino process involved consecutive addition–elimination, intramolecular… read more here.
Keywords: selective synthesis; domino; promoted selective; synthesis pyranones ... See more keywords
Selenosilane-Promoted Selective Mild Transformation of N-Thiophthalimides into Symmetric Disulfides
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DOI: 10.1055/s-0037-1610354
Abstract: The reactivity of N-thiophthalimides with silyl chalcogenides is described. Treatment of N-thiophthalimides with bis(trimethylsilyl) sulfide [(Me3Si)2S] leads to the formation of a mixture of the corresponding disulfides and trisulfides. On the other hand, N-thiophthalimides react… read more here.
Keywords: transformation thiophthalimides; selective mild; selenosilane promoted; thiophthalimides symmetric ... See more keywords
A study of the DIBAL-promoted selective debenzylation of α-cyclodextrin protected with two different benzyl groups
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.165
Abstract: An α-cyclodextrin protected with 2,4-dichlorobenzyl groups on the primary alcohols and ordinary benzyl groups on the secondary alcohols was prepared and subjected to DIBAL (diisobutylaluminum hydride)-promoted selective debenzylation. Debenzylation proceeded by first removing two dichlorobenzyl… read more here.
Keywords: benzyl; selective debenzylation; benzyl groups; cyclodextrin protected ... See more keywords