DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.02.057
Abstract: Abstract An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the… read more here.
Keywords: synthesis; promoted tandem; polysubstituted pyrroles; synthesis polysubstituted ... See more keywords
Mild Base-Promoted Tandem Nucleophilic Substitution/Decarboxylation/Hydroamination: Access to 3-Sulfonylindoles and 2-Methyleneindophenols.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03472
Abstract: We have developed an efficient construction of 3-sulfonylindoles and 2-methyleneindophenols via decarboxylative propargylation/hydroamination of ethynyl benzoxazinanones using sodium sulfonates and phenols as the nucleophiles. The reaction featured mild conditions (K2CO3), simple operation, and high chemoselectivity… read more here.
Keywords: tandem nucleophilic; mild base; hydroamination; promoted tandem ... See more keywords
Base-Promoted Tandem SNAr/Boulton-Katritzky Rearrangement: Access to [1,2,4]Triazolo[1,5-a]pyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00863
Abstract: A base-promoted tandem SNAr/Boulton-Katritzky rearrangement is developed. It offers a simple and straightforward method for the formation of functionalized [1,2,4]triazolo[1,5-a]pyridines from 1,2,4-oxadiazol-3-amines or 3-aminoisoxazoles with 2-fluoropyridines. read more here.
Keywords: base promoted; boulton katritzky; katritzky rearrangement; snar boulton ... See more keywords