Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.165
Abstract: A decline in intracellular nicotinamide adenine mononucleotide (NAD+) causes adipose tissue dysfunction. Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the NAD+ biosynthesis pathway. However, the molecular mechanism that mediates regulation of NAMPT expression in… read more here.
Keywords: promoter activity; expression; promoter; intracellular camp ... See more keywords
The genetic diversity within the 1.4 kb HLA-G 5′ upstream regulatory region moderately impacts on cellular microenvironment responses
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24009-7
Abstract: The HLA-G 5’URR extending 1.4 kb from the ATG presents a unique set of regulatory elements among HLA genes. Several variable sites have been described that coincide with or are close to these elements, thus HLA-G… read more here.
Keywords: promoter activity; hla urr; hla; shla levels ... See more keywords
Androgens downregulate anti-Müllerian hormone promoter activity in the Sertoli cell through the androgen receptor and intact steroidogenic factor 1 sites†
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy152
Abstract: Abstract Testicular anti-Müllerian hormone (AMH) production is inhibited by androgens around pubertal onset, as observed under normal physiological conditions and in patients with precocious puberty. In agreement, AMH downregulation is absent in patients with androgen… read more here.
Keywords: promoter activity; androgen receptor; activity; promoter ... See more keywords
C/EBPα promotes triacylglycerol synthesis via regulating PPARG promoter activity in goat mammary epithelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac412
Abstract: CCAAT/enhancer binding protein α (C/EBPα) is the key transcription factor involved in lipid metabolism, however, the role of C/EBPα in milk fat synthesis of dairy goats remains unknown. The objective of the present research was… read more here.
Keywords: promoter; pparg promoter; synthesis; ebp ... See more keywords
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac482
Abstract: Abstract We have investigated the function of human topoisomerase 1 (TOP1) in regulation of G-quadruplex (G4) formation in the Pu27 region of the MYC P1 promoter. Pu27 is among the best characterized G4 forming sequences… read more here.
Keywords: promoter; myc promoter; pu27; formation ... See more keywords
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001304
Abstract: A hypoxic tumor microenvironment (TME) promotes cancer progression, yet its value as a therapeutic target remains underexploited. Tripartite motif-containing 72 (TRIM72) may protect cells against various stresses including hypoxia. Recently, low TRIM72 expression has been… read more here.
Keywords: lactate production; trim72; breast cancer; promoter activity ... See more keywords
Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical research"
DOI: 10.2220/biomedres.41.217
Abstract: Taste-2 receptors (TAS2Rs), which belong to the G-protein coupled receptor (GPCR) family, are receptors for bitter taste perception. The aim of this study was to investigate whether zinc deficiency affects the expression of TAS2R genes.… read more here.
Keywords: promoter activity; zinc dependent; zinc; promoter ... See more keywords
A Genome-Wide Investigation of Effects of Aberrant DNA Methylation on the Usage of Alternative Promoters in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.780266
Abstract: Background The alternative usage of promoters provides a way to regulate gene expression, has a significant influence on the transcriptome, and contributes to the cellular transformation of cancer. However, the function of alternative promoters (APs)… read more here.
Keywords: usage; methylation; dna methylation; promoter activity ... See more keywords
Genetic Diversity of the LTR Region of Polish SRLVs and Its Impact on the Transcriptional Activity of Viral Promoters
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DOI: 10.3390/v15020302
Abstract: A long terminal repeat (LTR) plays an indispensable role in small ruminant lentivirus (SRLV) gene expression. In this study, we present the LTR sequence of Polish SRLVs representing different subtypes, and analyzed their impact on… read more here.
Keywords: promoter; genetic diversity; polish srlvs; ltr ... See more keywords
Zika virus NS2A and NS4A are the major antagonists that reduce IFN-β promoter activity induced by the MDA5/RIG-I signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1909.09017
Abstract: Zika virus (ZIKV) is a mosquito-transmitted emerging Flavivirus causing the Guillain-Barré syndrome and microcephaly in adults and fetuses, respectively. Since ZIKV was first isolated in 1947, severe outbreaks have occurred at various places worldwide, including… read more here.
Keywords: promoter activity; rig; mda5 rig; ns2a ns4a ... See more keywords