Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
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DOI: 10.1002/ijc.35424
Abstract: Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that… read more here.
Keywords: promoter communication; cancer; deregulated enhancer; enhancer promoter ... See more keywords
Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D.
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DOI: 10.1016/j.molcel.2019.05.032
Abstract: During embryogenesis, precise gene transcription in space and time requires that distal enhancers and promoters communicate by physical proximity within gene regulatory landscapes. To achieve this, regulatory landscapes fold in nuclear space, creating complex 3D… read more here.
Keywords: promoter communication; regulatory landscapes; enhancer promoter; promoter ... See more keywords
Mechanisms of enhancer-promoter communication and chromosomal architecture in mammals and Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1081088
Abstract: The spatial organization of chromosomes is involved in regulating the majority of intranuclear processes in higher eukaryotes, including gene expression. Drosophila was used as a model to discover many transcription factors whose homologs play a… read more here.
Keywords: mechanisms enhancer; promoter communication; enhancer promoter; architecture mammals ... See more keywords