Elucidation of the hetero-dimeric binding activity of LasR and RhlR proteins with the promoter DNA and the role of a specific Phe residue during the biosynthesis of HCN synthase from opportunistic pathogen Pseudomonas aeruginosa
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DOI: 10.1007/s00894-021-04701-8
Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen. It causes secondary infections in patients suffering from cancer and other immunological disorders. The pathogenicity of the organism is dependent on the ability of the organism to code… read more here.
Keywords: rhlr; hcn synthase; pseudomonas aeruginosa; promoter dna ... See more keywords
Aberrant DNA methylation of M1-macrophage genes in coronary artery disease
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DOI: 10.1038/s41598-018-38040-1
Abstract: M1 and M2 macrophage balance in atherosclerosis has attracted much interest. Though, it remains unknown how macrophage heterogeneity is regulated. Moreover, the regulation of macrophage polarization and activation also involve DNA methylation. However, it remains… read more here.
Keywords: promoter dna; methylation; dna methylation; macrophage ... See more keywords
PPARGC1A promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome
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DOI: 10.1515/hmbci-2020-0076
Abstract: Abstract Objectives Reduced gene expression of PPARGC1A in subjects with insulin resistance (IR) has been reported. Insulin resistance occurs early on the course of Turner syndrome (TS). The main objective of this study was to… read more here.
Keywords: ppargc1a promoter; dna methylation; promoter dna; dna ... See more keywords
Promoter DNA Methylation in GWAS-Identified Genes as Potential Functional Elements for Blood Pressure: An Observational and Mendelian Randomization Study
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DOI: 10.3389/fgene.2021.791146
Abstract: Genome-wide association studies have identified numerous genetic loci for blood pressure (BP). However, the relationships of functional elements inside these loci with BP are not fully understood. This study represented an effort to determine if… read more here.
Keywords: study; methylation; methylation levels; blood ... See more keywords
Structural Analysis of Ino2p/Ino4p Mutual Interactions and Their Binding Interface with Promoter DNA
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DOI: 10.3390/ijms23147600
Abstract: Gene expression is mediated by a series of regulatory proteins, i.e., transcription factors. Under different growth conditions, the transcriptional regulation of structural genes is associated with the recognition of specific regulatory elements (REs) in promoter… read more here.
Keywords: promoter dna; analysis; dna; ino2p ino4p ... See more keywords
Comprehensive Analysis of FASN in Tumor Immune Infiltration and Prognostic Value for Immunotherapy and Promoter DNA Methylation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415603
Abstract: Fatty acid synthase (FASN) promotes tumor progression in multiple cancers. In this study, we comprehensively examined the expression, prognostic significance, and promoter methylation of FASN, and its correlation with immune cell infiltration in pan-cancer. Our… read more here.
Keywords: infiltration; methylation; immunotherapy; promoter dna ... See more keywords