Development of a compact bidirectional promoter-driven dual chimeric antigen receptor (CAR) construct targeting CD19 and CD20 in the Sleeping Beauty (SB) transposon system
Sign Up to like & getrecommendations! Published in 2024 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2023-008555
Abstract: Background A bidirectional promoter-driven chimeric antigen receptor (CAR) cassette provides the simultaneous expression of two CARs, which significantly enhances dual antigen-targeted CAR T-cell therapy. Methods We developed a second-generation CAR directing CD19 and CD20 antigens,… read more here.
Keywords: promoter driven; bidirectional promoter; promoter; cd19 cd20 ... See more keywords
P1 promoter-driven HNF4α isoforms are specifically repressed by β-catenin signaling in colorectal cancer cells
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DOI: 10.1242/jcs.214734
Abstract: ABSTRACT HNF4α is a key nuclear receptor for regulating gene expression in the gut. Although both P1 and P2 isoform classes of HNF4α are expressed in colonic epithelium, specific inhibition of P1 isoforms is commonly… read more here.
Keywords: isoforms specifically; catenin; colorectal cancer; hnf4 ... See more keywords
Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
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DOI: 10.3389/fcell.2022.914386
Abstract: Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to-neuron… read more here.
Keywords: promoter; glia neuron; driven aav; retina ... See more keywords
Serum Amyloid A3 Promoter-Driven Luciferase Activity Enables Visualization of Diabetic Kidney Disease
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DOI: 10.3390/ijms23020899
Abstract: The early detection of diabetic nephropathy (DN) in mice is necessary for the development of drugs and functional foods. The purpose of this study was to identify genes that are significantly upregulated in the early… read more here.
Keywords: promoter; stz; serum amyloid; driven luciferase ... See more keywords