Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7113-8_10
Abstract: Excessive deposition of extracellular matrix (ECM) is a common hallmark of fibrotic diseases in various organs. Chiefly among this ECM are collagen types I and III, secreted by local fibroblasts, and other mesenchymal cells recruited… read more here.
Keywords: characterization mesenchymal; fibroblast cells; mesenchymal fibroblast; promoter enhancer ... See more keywords
Systematic Functional Interrogation of Genes in GWAS Loci Identified ATF1 as a Key Driver in Colorectal Cancer Modulated by a Promoter-Enhancer Interaction.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.05.004
Abstract: Genome-wide association studies (GWASs) have identified approximately 100 colorectal cancer (CRC) risk loci. However, the causal genes in these loci have not been systematically interrogated. We conducted a high-throughput RNA-interference functional screen to identify the… read more here.
Keywords: risk; enhancer interaction; interaction; promoter enhancer ... See more keywords
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.014
Abstract: The prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a short isoform of long noncoding RNA PCAT19 (PCAT19-short), which is… read more here.
Keywords: pcat19; risk snp; promoter enhancer; promoter ... See more keywords
Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adl4043
Abstract: Sequencing-based mapping of ensemble pairwise interactions among regulatory elements support the existence of topological assemblies known as promoter-enhancer hubs or cliques in cancer. Yet, prevalence, regulators, and functions of promoter-enhancer hubs in individual cancer cells… read more here.
Keywords: enhancer hubs; cancer; enhancer; promoter enhancer ... See more keywords
Abstract 2464: Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2464
Abstract: Long non-coding RNAs (lncRNAs), longer than 200 nucleotides in length, function in a wide range of processes by diverse mechanisms. lncRNAs are attracting research interest in the field of cancer research though their roles in… read more here.
Keywords: mymlr; regulates myc; promoter enhancer; cancer ... See more keywords
Hemogen /BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014308
Abstract: Hemogen, also known as EDAG, is a hematopoietic tissue-specific gene that regulates the proliferation and differentiation of hematopoietic cells. However, the mechanism underlying hemogen function in erythropoiesis is unknown. We found that depletion of hemogen… read more here.
Keywords: hemogen brg1; promoter enhancer; erythropoiesis; hemogen ... See more keywords