Abnormal promoter DNA hypermethylation of the integrin, nidogen, and dystroglycan genes in breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81851-y
Abstract: Cell transmembrane receptors and extracellular matrix components play a pivotal role in regulating cell activity and providing for the concerted integration of cells in the tissue structures. We have assessed DNA methylation in the promoter… read more here.
Keywords: promoter hypermethylation; promoter; hypermethylation; abnormal promoter ... See more keywords
Microsatellite Instability and Promoter Hypermethylation of DNA repair genes in Hematologic Malignancies: a forthcoming direction toward diagnostics
Sign Up to like & getrecommendations! Published in 2018 at "Hematology"
DOI: 10.1080/10245332.2017.1354428
Abstract: ABSTRACT Objective: The objective of our review is to highlight the significance of microsatellite hypervariation in diagnostics of hematologic malignancies. Methods: For the past few decades, extensive experiments in cancer research have explored all the… read more here.
Keywords: promoter hypermethylation; dna repair; hematologic malignancies; repair ... See more keywords
BRCA1 promoter hypermethylation in human placenta: A hidden link with β-hCG expression.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz117
Abstract: Gestational Trophoblastic Diseases (GTD) is group of pregnancy related tumors characterized by abnormal levels of "β-hCG" with higher incidence in South-East Asia, especially India. Our laboratory has reported that wild type BRCA1 transcriptionally regulates β-hCG… read more here.
Keywords: promoter hypermethylation; brca1; hcg; expression ... See more keywords
Promoter hypermethylation of MGMT gene may contribute to the pathogenesis of gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006708
Abstract: Beckground: The association of MGMT (O6-methyguanine deoxyribonucleic acid methyltransferase) promoter hypermethylation with gastric cancer (GC) risk has been studied extensively, but the results remained unclear. Here, we performed a meta-analysis to evaluate whether promoter hypermethylation… read more here.
Keywords: promoter hypermethylation; mgmt gene; promoter;
Associations of RASSF1A, RARβ, and CDH1 promoter hypermethylation with oral cancer risk
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000009971
Abstract: Abstract Background: Oral tumor is a heterogeneous group of tumors, in which it has several different histopathological and molecular features. Recently, genetic and epigenetic alterations are often detected in the development of oral cancer. Gene… read more here.
Keywords: promoter hypermethylation; oral cancer; cdh1 promoter; promoter ... See more keywords
Promoter Hypermethylation of the Eyes Absent 4 Gene is a Tumor-Specific Epigenetic Biomarker in Iranian Colorectal Cancer Patients.
Sign Up to like & getrecommendations! Published in 2018 at "Acta medica Iranica"
DOI: 10.18502/acta.v57i5.1874
Abstract: The aim of this study was to investigate whether hypermethylation of Eyes Absent 4 (EYA4) is also implicated in Iranian Colorectal Cancer (CRC) patients or not. From fresh frozen tissues, samples from 38 paired (cancer… read more here.
Keywords: promoter hypermethylation; hypermethylation; hypermethylation eyes; cancer ... See more keywords
Validation of SFRP1 Promoter Hypermethylation in Plasma as a Prognostic Marker for Survival and Gemcitabine Effectiveness in Patients with Stage IV Pancreatic Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13225717
Abstract: Simple Summary Pancreatic adenocarcinoma (PDAC) is a disease with an incredibly grim prognosis. Most patients die within one year of receiving the diagnosis. There are currently very few tools to help the clinician decide between… read more here.
Keywords: promoter hypermethylation; validation; pancreatic adenocarcinoma; promoter ... See more keywords
Evaluation of promoter hypermethylation of tumor suppressor gene BRCA1 in epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_390_20
Abstract: Context: Epithelial ovarian cancer (EOC) is a serious gynecological issue worldwide and its late detection is the major encumbrance in treatment procedures. Hypermethylation-mediated BRCA1 gene silencing results in failure of the repair system of damaged… read more here.
Keywords: epithelial ovarian; promoter hypermethylation; brca1 gene; gene ... See more keywords
PTEN Promoter Hypermethylation Is Associated with Breslow Thickness in Acral Melanoma on the Heel, Forefoot, and Hallux
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DOI: 10.5021/ad.2021.33.1.18
Abstract: Background Acral melanoma occurs on glabrous skin or the nail apparatus and is distinct from ultraviolet-related melanoma due to differing genetic alteration patterns. Although the pathogenesis of acral melanoma is not well understood, mechanical stress… read more here.
Keywords: melanoma; acral melanoma; pten promoter; promoter hypermethylation ... See more keywords