Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter-methylated malignant astrocytoma.
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa033
Abstract: BACKGROUND O6-methylguanine DNA-methyl transferase (MGMT) promoter methylation status is predictive for alkylating chemotherapy, but there are non-benefitting subgroups. METHODS This is the long-term update of NOA-08 (NCT01502241) that compared efficacy and safety of radiotherapy (RT,… read more here.
Keywords: methylation; mgmt promoter; radiotherapy; promoter methylated ... See more keywords
A novel epigenetic biomarker, plasma miR-138-5p gene promoter-methylated DNA, for colorectal cancer diagnosis.
Sign Up to like & getrecommendations! Published in 2022 at "Personalized medicine"
DOI: 10.2217/pme-2021-0095
Abstract: Aim: The miR-138-5p promoter-methylated DNA level, miR-138-5p and PDL1 expression were investigated in colorectal cancer (CRC) patients. Materials & methods: miR-138-5p promoter methylation status and miR-138-5p expression were investigated using the MethyLight and qPCR method,… read more here.
Keywords: mir 138; methylated dna; promoter methylated; plasma ... See more keywords