Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12909
Abstract: Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit… read more here.
Keywords: methylation; testicular germ; promoter methylation; germ cell ... See more keywords
Prognostic and predictive impact of MGMT promoter methylation status in high risk grade II glioma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-022-03955-3
Abstract: MGMT promoter methylation has been associated with favorable prognosis and survival outcomes in patients with glioblastoma and WHO grade III glioma. However, the effects of promoter methylation of MGMT in patients with WHO grade II… read more here.
Keywords: methylation; grade glioma; prognostic predictive; mgmt ... See more keywords
Validation of CSN1S1 transcriptional expression, promoter methylation, and prognostic power in breast cancer using independent datasets
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100867
Abstract: Breast cancer ranked second among most frequent cancer in the world playing a significant role in mortality rate. Having prior knowledge on differentially expressed genes in breast cell carcinoma elucidated important indications to understand the… read more here.
Keywords: cancer; promoter methylation; expression; breast cancer ... See more keywords
The utilization of MGMT promoter methylation testing in United States hospitals for glioblastoma and its impact on prognosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.02.009
Abstract: Multiple studies have identified O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status to be an important prognostic factor in glioblastoma (GBM). We used the National Cancer Data Base (NCDB) to analyze completeness of coding for MGMT as… read more here.
Keywords: status; mgmt; mgmt promoter; promoter methylation ... See more keywords
Prognostic and predictive impact of MGMT promoter methylation in grade 3 gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.12.028
Abstract: BACKGROUND Grade 3 gliomas are aggressive primary brain tumors. Promoter methylation of methyl guanine methyl transferase (MGMT) has been associated with a favorable prognosis in patients with glioblastoma, but the impact of MGMT promoter methylation… read more here.
Keywords: methylation; grade glioma; mgmt; promoter methylation ... See more keywords
Machine learning-based radiomic, clinical and semantic feature analysis for predicting overall survival and MGMT promoter methylation status in patients with glioblastoma.
Sign Up to like & getrecommendations! Published in 2020 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2020.09.017
Abstract: INTRODUCTION Survival varies in patients with glioblastoma due to intratumoral heterogeneity and radiomics/imaging biomarkers have potential to demonstrate heterogeneity. The objective was to combine radiomic, semantic and clinical features to improve prediction of overall survival… read more here.
Keywords: status; patients glioblastoma; mgmt promoter; mgmt ... See more keywords
Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2021.09.005
Abstract: PURPOSE To investigate the feasibility for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas(GBMs) by intravoxel incoherent motion(IVIM) and dynamic susceptibility contrast(DSC). METHODS Preoperative IVIM and DSC images of 71 patients(IDH… read more here.
Keywords: idh mutation; mgmt promoter; promoter methylation; mutation ... See more keywords
Sensitive Detection and Conjoint Analysis of Promoter Methylation by Conjugated Polymers for Differential Diagnosis and Prognosis of Glioma.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c03218
Abstract: Glioma is the most common primary tumor in the central nervous system (CNS) with the worst prognosis. Accurate pathological diagnosis has always been a challenge for optimal management of glioma. Promoter methylation is an important… read more here.
Keywords: prognosis; promoter methylation; glioma; diagnosis ... See more keywords
Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57920-z
Abstract: Pathological staging and histological grading systems are useful, but imperfect, predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Aberrant promoter methylation is the main type of epigenetic modification that plays a role… read more here.
Keywords: methylation; neuropeptide receptor; methylation status; promoter methylation ... See more keywords
A case of aggressive pituitary neuroendocrine tumour with extremely rapid progression: possible diagnostic value of TERT promoter methylation.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2022.2151564
Abstract: Most pituitary adenoma/neuroendocrine tumours (PitNET) are histologically benign and grow slowly; however, a subset of these tumours exhibit a more aggressive clinical course characterized by local invasiveness and early recurrence. These high-risk PitNETs often require… read more here.
Keywords: tert promoter; extremely rapid; case; promoter methylation ... See more keywords
LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2078728
Abstract: Abstract Objectives This study aimed to explore the underlying role and mechanism of LINC00313 in osteoarthritis (OA) progression. Methods CHON-001 chondrocytes were treated with interleukin (IL)-1β to induce OA in vitro, and then transfected with… read more here.
Keywords: signaling pathway; promoter methylation; jnk signaling; jnk ... See more keywords