Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.03.007
Abstract: Heat shock instantly reprograms transcription. Whether gene and enhancer transcription fully recover from stress and whether stress establishes a memory by provoking transcription regulation that persists through mitosis remained unknown. Here, we measured nascent transcription… read more here.
Keywords: transcription; pause release; promoter proximal; stress ... See more keywords
Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1272
Abstract: Promoter-proximal Polymerase II (Pol II) pausing is a key rate limiting step for gene expression. DNA and RNA-binding trans-acting factors regulating the extent of pausing have been identified. However, we lack a quantitative model of… read more here.
Keywords: transcriptional elongation; promoter proximal; pol pausing; regulatory factors ... See more keywords
PAF1 regulation of promoter-proximal pause release via enhancer activation
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan3269
Abstract: Multitalented enhancers Productive transcription from DNA demands initiation, elongation, and termination. Enhancers are DNA sequences that loop with promoters to initiate transcription. Chen et al. show that enhancers also regulate gene expression by modulating transcription… read more here.
Keywords: promoter proximal; release paused; enhancer activation; paf1 ... See more keywords
HSV-1 Infection Induces a Downstream Shift of Promoter-Proximal Pausing for Host Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00381-23
Abstract: This study provides a genome-wide analysis of changes in promoter-proximal polymerase II (Pol II) pausing on host genes induced by HSV-1 infection. It shows that standard measures of pausing, i.e., pausing indices, do not properly… read more here.
Keywords: infection; hsv infection; promoter proximal; pol pausing ... See more keywords
RNA Polymerase II Promoter-Proximal Pausing and Release to Elongation Are Key Steps Regulating Herpes Simplex Virus 1 Transcription
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DOI: 10.1128/jvi.02035-19
Abstract: These data suggest that viral transcription is regulated not only by Pol II recruitment to viral genes but also by control of elongation into viral gene bodies. We provide a detailed map of Pol II… read more here.
Keywords: expression; promoter proximal; occupancy; gene ... See more keywords
Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303419
Abstract: Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the… read more here.
Keywords: drosophila; tumorous growth; promoter proximal; proximal pausing ... See more keywords