Promoter Recognition: Putting TFIID on the Spot.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.06.004
Abstract: Basal transcription factor TFIID connects transcription activation to the assembly of the RNA polymerase II preinitiation complex at the core promoter of genes. The mechanistic understanding of TFIID function and dynamics has been limited by… read more here.
Keywords: promoter recognition; recognition putting; tfiid spot; tfiid ... See more keywords
Supervised promoter recognition: a benchmark framework
Sign Up to like & getrecommendations! Published in 2022 at "BMC Bioinformatics"
DOI: 10.1186/s12859-022-04647-5
Abstract: Motivation Deep learning has become a prevalent method in identifying genomic regulatory sequences such as promoters. In a number of recent papers, the performance of deep learning models has continually been reported as an improvement… read more here.
Keywords: promoter recognition; promoter; supervised promoter; framework ... See more keywords
Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009644
Abstract: Transcription of the ~200 mouse and human ribosomal RNA genes (rDNA) by RNA Polymerase I (RPI/PolR1) accounts for 80% of total cellular RNA, around 35% of all nuclear RNA synthesis, and determines the cytoplasmic ribosome… read more here.
Keywords: promoter; sl1; ubtf e210k; rdna ... See more keywords