Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9666-7_13
Abstract: Growing evidence suggests the existence of G-quadruplexes and their involvement in transcriptional regulation of many human genes, including VEGF. These studies also provide strong evidence that G-quadruplex structures are stabilized by binding to small molecules,… read more here.
Keywords: promoter region; transcription; interactive agents; quadruplex interactive ... See more keywords
A SNP in the promoter region of theVvmybA1 gene is responsible for differences in grape berry color between two related bud sports of grape
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DOI: 10.1007/s10725-017-0272-5
Abstract: The VvmybA1 gene in grape (Vitis vinifera) plays a key role in the biosynthesis of anthocyanin. The grape cultivars, ‘Benitaka’ (red color) and ‘Brazil’ (black color) were the result of a bud mutation. ‘Benetika’ was… read more here.
Keywords: promoter region; color; grape; embryos transformed ... See more keywords
A novel mutation (-195C>A) in the promoter region of CFTR gene is associated with Chinese Congenital Bilateral Absence of Vas Deferens (CBAVD).
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144007
Abstract: Congenital bilateral absence of vas deferens (CBAVD), a frequent cause of obstructive azoospermia and male infertility in Chinese, is mainly due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This study aim… read more here.
Keywords: promoter region; gene; cftr gene; region cftr ... See more keywords
Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors.
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DOI: 10.1016/j.gene.2020.145322
Abstract: Abstract T-box 5 (TBX5) protein belongs to the T-box family whose members play a crucial role in cell-type specification, morphogenesis and organogenesis. TBX5 is a transcription factor important for cardiac development and upper limbs formation… read more here.
Keywords: promoter region; transcription; tbx5; box ... See more keywords
Hypomethylation of C1q/tumor necrosis factor-related protein-1 promoter region in whole blood and risks for coronary artery aneurysms in Kawasaki disease.
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DOI: 10.1016/j.ijcard.2020.02.002
Abstract: BACKGROUND Kawasaki disease (KD) is characterized as a self-limited systemic vasculitis. C1q/tumor necrosis factor-related protein-1 (CTRP1) had been associated with the occurrence of vasculitis in KD. Methylation at the promoter region of certain genes was… read more here.
Keywords: promoter region; methylation; group; methylation levels ... See more keywords
In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene
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DOI: 10.1021/acsomega.6b00531
Abstract: Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich segment of nuclease hypersensitive element (NHE III1), that is, “Pu27”, which is localized… read more here.
Keywords: myc oncogene; promoter region; structure formed; quadruplex structure ... See more keywords
NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle
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DOI: 10.1038/s41598-017-08384-1
Abstract: The SIX1 homeobox gene belongs to the six homeodomain family and is widely thought to play a principal role in mediating of skeletal muscle development. In the present study, we determined that the bovine SIX1… read more here.
Keywords: promoter region; gene; qinchuan cattle; six1 gene ... See more keywords
35 Characterization of the promoter region of ZNFO, an oocyte-specific gene in cattle
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DOI: 10.1071/rdv33n2ab35
Abstract: Maternal factors are essential aspects of oocyte competence, which orchestrate early embryonic development. ZNFO is a Kruppel-associated box domain (KRAB) containing zinc finger transcription factor, which is exclusively expressed in bovine oocyte. Previous studies have… read more here.
Keywords: core promoter; promoter region; transcription; promoter ... See more keywords
STOX1 promotor region -922 T > C polymorphism is associated with Early-Onset preeclampsia
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DOI: 10.1080/01443615.2022.2141612
Abstract: Abstract Preeclampsia (PE), affecting 5–8% of pregnancies, is a common pregnancy disease that has harmful effects on mother and foetus. It has been found that the STOX1 (Storkhead Box 1), which is a transcription factor,… read more here.
Keywords: gene; stox1; polymorphism; early onset ... See more keywords
A 67-bp variable duplication in the promoter region of the ADIPOQ is associated with milk traits in Xinjiang brown cattle.
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DOI: 10.1080/10495398.2020.1868487
Abstract: Adiponectin, also known as ADIPOQ, is a hormone protein secreted by adipocytes. The ADIPOQ gene is expressed primarily in adipose tissue, and the encoded protein circulates in the bloodstream and has the potential to regulate… read more here.
Keywords: milk; promoter region; duplication promoter; variable duplication ... See more keywords
Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma
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DOI: 10.1080/15548627.2020.1741318
Abstract: ABSTRACT Children with ependymoma have high mortality rates because ependymoma is resistant to conventional therapy. Genomic and transcriptomic studies have identified potential targets as significantly altered genes in ependymoma patients. Although several candidate oncogenes in… read more here.
Keywords: protein; promoter region; tpr; region nuclear ... See more keywords