Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer
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DOI: 10.1093/nar/gkac090
Abstract: Abstract DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures over other types of… read more here.
Keywords: promoter; promoter telomere; antitumor activity; myc promoter ... See more keywords