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   Articles with "promoter usage" as a keyword



The effect of genetic variation on promoter usage and enhancer activity

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-01467-7

Abstract: The identification of genetic variants affecting gene expression, namely expression quantitative trait loci (eQTLs), has contributed to the understanding of mechanisms underlying human traits and diseases. The majority of these variants map in non-coding regulatory… read more here.

Keywords: enhancer activity; promoter usage; genetic variation; promoter ... See more keywords

Gene duplication captures morph-specific promoter usage in the evolution of aphid wing dimorphisms

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2420893122

Abstract: Significance A key challenge in the field of evolutionary developmental biology is identifying the types of genetic changes that lead to morphological evolution. The field currently focuses on the role of regulatory changes in this… read more here.

Keywords: evolution; usage evolution; evolution aphid; aphid wing ... See more keywords

Prediction and annotation of alternative transcription starts and promoter shift in the chicken genome

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recommendations! Published in 2025 at "Journal of bioinformatics and computational biology"

DOI: 10.1142/s0219720025500040

Abstract: Promoter shifting, characterized by alterations in Transcription Start Site (TSS) coordinates, is a well-documented phenomenon. The impact and statistical significance of promoter shifting can be assessed through analysis of Cap Analysis of Gene Expression (CAGE)… read more here.

Keywords: promoter; expression; differential promoter; gene ... See more keywords

NF-κB Signaling and IL-4 Signaling Regulate SATB1 Expression via Alternative Promoter Usage During Th2 Differentiation

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recommendations! Published in 2019 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2019.00667

Abstract: SATB1 is a genome organizer protein that is expressed in a lineage specific manner in CD4+ T-cells. SATB1 plays a crucial role in expression of multiple genes throughout the thymic development and peripheral differentiation of… read more here.

Keywords: promoter usage; via alternative; expression; differentiation ... See more keywords

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

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recommendations! Published in 2019 at "eLife"

DOI: 10.7554/elife.41673

Abstract: Genetic variants regulating RNA splicing and transcript usage have been implicated in both common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have been mapped across multiple cell types and contexts, it is… read more here.

Keywords: transcript usage; promoter usage; usage; complex traits ... See more keywords