Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.006
Abstract: N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized to many promoters and… read more here.
Keywords: m6a modification; promoters enhancers; integrator; m6a ... See more keywords
Repurposing of promoters and enhancers during mammalian evolution
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06544-z
Abstract: Promoters and enhancers—key controllers of gene expression—have long been distinguished from each other based on their function. However, recent work suggested that common architectural and functional features might have facilitated the conversion of one type… read more here.
Keywords: regulatory repurposing; evolution; promoters enhancers; enhancers mammalian ... See more keywords
A model of active transcription hubs that unifies the roles of active promoters and enhancers.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab235
Abstract: An essential questions of gene regulation is how large number of enhancers and promoters organize into gene regulatory loops. Using transcription-factor binding enrichment as an indicator of enhancer strength, we identified a portion of H3K27ac… read more here.
Keywords: active transcription; promoters enhancers; transcription hubs; active promoters ... See more keywords