Abstract 3702: Serine promotes aggressive phenotype in renal cancer
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DOI: 10.1158/1538-7445.am2023-3702
Abstract: Tumor cells are known to have increased demand for nutrients to support proliferation. Among the most highly utilized nutrients by tumor cells are nonessential amino acids (NEAAs). While the role of NEAAs in supporting tumor… read more here.
Keywords: aggressive phenotype; promotes aggressive; serine promotes; serine ... See more keywords
Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding
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DOI: 10.1172/jci.insight.151583
Abstract: Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic… read more here.
Keywords: aggressive features; promotes aggressive; integrin binding; loss ... See more keywords