L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression
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DOI: 10.1136/jitc-2021-003957
Abstract: Background The repression or downregulation of programmed death-ligand 1 (PD-L1) can release its inhibition of T cells and activate antitumor immune responses. Although PD-1 and PD-L1 antibodies are promising treatments for diverse tumor types, their… read more here.
Keywords: hydroxytryptophan promotes; effect; promotes antitumor; htp ... See more keywords
Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression
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DOI: 10.1158/2326-6066.cir-21-0831
Abstract: WTX 124 is an inducible IL-2 prodrug that is selectively activated in the tumor microenvironment. Administration of WTX-124 generates potent antitumor immunity by activating tumor-infiltrating lymphocytes while preventing the toxicity associated with systemic, high dose… read more here.
Keywords: activated promotes; promotes antitumor; discovery conditionally; immunity ... See more keywords
HDAC3 Inhibition Promotes Antitumor Immunity by Enhancing CXCL10-Mediated Chemotaxis and Recruiting of Immune Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0317
Abstract: Histone deacetylase 3 (HDAC3) is shown to regulate expression of genes encoding chemokines CXCL9/10/11, as well as impact antitumor immune–cell recruitment in the tumor microenvironment. The data highlight how targeting HDAC3 could boost antitumor immune… read more here.
Keywords: promotes antitumor; inhibition promotes; hdac3 inhibition; immunity enhancing ... See more keywords