PCSK9 promotes arterial medial calcification.
Sign Up to like & getrecommendations! Published in 2022 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2022.01.015
Abstract: BACKGROUND AND AIMS A complex interplay among chronic kidney disease (CKD), lipid metabolism and aortic calcification has been recognized. Here we investigated the influence of kidney function on PCSK9 levels and its potential direct action… read more here.
Keywords: pcsk9; promotes arterial; calcification; pro calcific ... See more keywords
JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac641
Abstract: AIMS Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary syndromes. JCAD promotes experimental atherosclerosis through the large tumor suppressor kinase 2 (LATS2)/Hippo pathway. This study investigates the role of JCAD… read more here.
Keywords: pi3k akt; promotes arterial; jcad; arterial thrombosis ... See more keywords
Endothelial SIRT6 deficiency promotes arterial thrombosis in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular and cellular cardiology"
DOI: 10.2139/ssrn.4127860
Abstract: OBJECTIVE Arterial thrombosis may be initiated by endothelial inflammation or denudation, activation of blood-borne elements or the coagulation system. Tissue factor (TF), a central trigger of the coagulation cascade, is regulated by the pro-inflammatory NF-κB-dependent… read more here.
Keywords: endothelial sirt6; promotes arterial; mice; thrombosis ... See more keywords