Hyperconjugation Promotes Catalysis in a Pyridoxal 5′-Phosphate-Dependent Enzyme
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DOI: 10.1021/acscatal.8b01911
Abstract: Pyridoxal 5′-phosphate (PLP)-dependent enzymes facilitate reaction specificity by aligning the scissile σ-bond of the PLP-substrate covalent complex perpendicular to the ring of the cofactor. Current models propose that this alignment causes a destabilization of the… read more here.
Keywords: catalysis pyridoxal; pyridoxal phosphate; promotes catalysis; hyperconjugation promotes ... See more keywords