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   Articles with "promotes differentiation" as a keyword



LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression

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recommendations! Published in 2024 at "Leukemia"

DOI: 10.1038/s41375-024-02167-0

Abstract: TO THE EDITOR: Infant leukemias present within the fi rst year of life as either acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). A majority are driven by KMT2A/MLL rearrangements (henceforth MLLr) that arise… read more here.

Keywords: mll enl; differentiation fully; lin28b; leukemia ... See more keywords
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LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis

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recommendations! Published in 2020 at "Cell Discovery"

DOI: 10.1038/s41421-020-00211-8

Abstract: Macrophages are mainly divided into two populations, which play a different role in physiological and pathological conditions. The differentiation of these cells may be regulated by transcription factors. However, it is unclear how to modulate… read more here.

Keywords: ly6c high; promotes differentiation; neg macrophages; inflammatory monocytes ... See more keywords

Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-12332-0

Abstract: The urothelium is an epithelial barrier lining the bladder that protects against infection, fluid exchange and damage from toxins. The nuclear receptor Pparg promotes urothelial differentiation in vitro, and Pparg mutations are associated with bladder… read more here.

Keywords: pparg; bladder; promotes differentiation; differentiation ... See more keywords

UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2422971122

Abstract: Significance This study sheds light on an important epigenetic regulator of skin epithelial differentiation and offers new insights into how a X-linked epigenetic regulator may contribute to skin homeostasis and disease. In finding that UTX… read more here.

Keywords: differentiation; differentiation noncatalytically; utx kdm6a; noncatalytically somatic ... See more keywords

Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.

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recommendations! Published in 2019 at "JCI insight"

DOI: 10.1172/jci.insight.127130

Abstract: Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing of neuroblastomas, we identified the… read more here.

Keywords: promotes differentiation; neuroblastoma; prohibitin promotes; differentiation potential ... See more keywords