LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis
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DOI: 10.1038/s41421-020-00211-8
Abstract: Macrophages are mainly divided into two populations, which play a different role in physiological and pathological conditions. The differentiation of these cells may be regulated by transcription factors. However, it is unclear how to modulate… read more here.
Keywords: ly6c high; promotes differentiation; neg macrophages; inflammatory monocytes ... See more keywords
Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
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DOI: 10.1038/s41467-019-12332-0
Abstract: The urothelium is an epithelial barrier lining the bladder that protects against infection, fluid exchange and damage from toxins. The nuclear receptor Pparg promotes urothelial differentiation in vitro, and Pparg mutations are associated with bladder… read more here.
Keywords: pparg; bladder; promotes differentiation; differentiation ... See more keywords
Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.
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DOI: 10.1172/jci.insight.127130
Abstract: Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing of neuroblastomas, we identified the… read more here.
Keywords: promotes differentiation; neuroblastoma; prohibitin promotes; differentiation potential ... See more keywords